NetworkTrail - a web service for identifying and visualizing deregulated subnetworks
NetworkTrail - a web service for identifying and visualizing deregulated subnetworks
复制标题
NetworkTrail - 用于识别和可视化解除管制的子网络的 Web 服务
DOI：
10.1093/bioinformatics/btt204
复制
发表时间：
2013
期刊：
影响因子：
5.8
通讯作者：
H. Lenhof
中科院分区：
文献类型：
--
作者：
D. Stöckel;Oliver Müller;Tim Kehl;A. Gerasch;C. Backes;Alexander Rurainski;A. Keller;Michael Kaufmann;H. Lenhof
未标记
生化途径的失调在许多疾病中起着核心作用，如癌症或帕金森氏病。计算这些去调控途径的计算机工具可能有助于获得对致病机制的新见解，并可能为个性化医学意义上的治疗分层开辟新途径。在这里，我们提出了NetworkTrail，一个Web服务，用于检测生物网络中的放松管制的途径和子图。NetworkTrail使用最先进的基于整数线性规划的方法来完成这项任务，并提供生物网络分析仪（BiNA）和Cytoscape Web的接口，以可视化所产生的子网络。通过为难以使用的命令行工具提供可访问的界面，新的Web服务使非专家能够快速可靠地进行此类网络分析。
可用性和执行
NetworkTrail是一个基于JavaServer Pages的Web服务。该算法已在C++中实现。NetworkTrail可在www.example.com上获得。
UNLABELLED
The deregulation of biochemical pathways plays a central role in many diseases like cancer or Parkinsons's disease. In silico tools for calculating these deregulated pathways may help to gain new insights into pathogenic mechanisms and may open novel avenues for therapy stratification in the sense of personalized medicine. Here, we present NetworkTrail, a web service for the detection of deregulated pathways and subgraphs in biological networks. NetworkTrail uses a state-of-the-art integer linear programming-based approach for this task and offers interfaces to the Biological Network Analyzer (BiNA) and Cytoscape Web for visualizing the resulting subnetworks. By providing an accessible interface to otherwise hard-to-use command line tools, the new web service enables non-experts to quickly and reliably carry out this type of network analyses.
AVAILABILITY AND IMPLEMENTATION
NetworkTrail is a JavaServer Pages-based web service. The algorithm for finding deregulated subnetworks has been implemented in C++. NetworkTrail is available at http://networktrail.bioinf.uni-sb.de/.
影响因子：
14.9
作者：
Backes C;Rurainski A;Klau GW;Müller O;Stöckel D;Gerasch A;Küntzer J;Maisel D;Ludwig N;Hein M;Keller A;Burtscher H;Kaufmann M;Meese E;Lenhof HP
通讯作者：
Lenhof HP