Evaluation of energy deposition and secondary particle production in proton therapy of brain using a slab head phantom
Evaluation of energy deposition and secondary particle production in proton therapy of brain using a slab head phantom
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DOI：
10.1016/j.rpor.2014.04.008
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发表时间：
2014-11-01
影响因子：
1.2
通讯作者：
Loushab, Mandy Ebrahimi
中科院分区：
文献类型：
--
作者：
Jia, Sayyed Bijan;Hadizadeh, Mohammad Hadi;Loushab, Mandy Ebrahimi
目的：评估质子在人脑中的能量沉积，并计算质子治疗中质子产生的二次中子和光子。背景：放射治疗是治疗局部癌症肿瘤的主要方法之一。大约 60 年前就提出了在放射治疗中使用高能质子束。近年来，人们对放射治疗这一主题的兴趣重新燃起。高能质子的角偏转很小，具有明确的穿透范围，在其轨迹末端，即布拉格峰，能量损失急剧增加。 材料和方法：使用板头模型来模拟脑组织中的质子治疗。在这项研究中，使用蒙特卡罗MCNPX代码进行了模拟。结果：通过使用单高能质子笔形束，计算或获得了组织中的能量沉积，特别是大脑内部的能量沉积，以及估计体内质子相互作用所产生的中子和光子及其能谱。测定了二次中子和光子从头部逸出的能量。结论：发现对于高能质子束，中子逸出的能量几乎是光子逸出的能量的10倍。我们估计，在 110 MeV 束流能量下，通过次级光子和中子从头部“泄漏”的总质子能量约为 1%。 (C) 2014 年大波兰癌症中心。由 Elsevier Urban & Partner Sp. 出版。 z o.o.版权所有。
Aim: Evaluation of energy deposition of protons in human brain and calculation of the secondary neutrons and photons produced by protons in proton therapy.Background: Radiation therapy is one of the main methods of treating localized cancer tumors. The use of high energy proton beam in radiotherapy was proposed almost 60 years ago. In recent years, there has been a revival of interest in this subject in the context of radiation therapy. High energy protons suffer little angular deflection and have a well-defined penetration range, with a sharp increase in the energy loss at the end of their trajectories, namely the Bragg peak.Materials and methods: A slab head phantom was used for the purpose of simulating proton therapy in brain tissue. In this study simulation was carried out using the Monte Carlo MCNPX code.Results: By using mono energetic proton pencil beams, energy depositions in tissues, especially inside the brain, as well as estimating the neutron and photon production as a result of proton interactions in the body, together with their energy spectra, were calculated or obtained. The amount of energy escaped from the head by secondary neutrons and photons was determined.Conclusions: It was found that for high energy proton beams the amount of escaped energy by neutrons is almost 10 times larger than that by photons. We estimated that at 110 MeV beam energy, the overall proton energy "leaked" from the head by secondary photons and neutrons to be around 1%. (C) 2014 Greater Poland Cancer Centre. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.