4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT.
4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT.
复制标题
DOI：
10.1109/tmi.2017.2690819
复制
发表时间：
2017-08
影响因子：
10.6
通讯作者：
King MA
中科院分区：
文献类型：
--
作者：
Qi W;Yang Y;Song C;Wernick MN;Pretorius PH;King MA
已知心脏SPECT图像遭受心脏和呼吸运动模糊。在这项工作中，我们研究了一种4D重建方法，以抑制呼吸运动的影响，在门控心脏SPECT成像。在该方法中，心脏门控图像的序列相对于呼吸周期中的参考呼吸幅度仓来重建。为了应对固有的高成像噪声的挑战，我们利用在整个呼吸周期期间采集的数据计数，通过使用运动补偿方案，其中考虑到心脏运动和呼吸运动。在我们的评估研究中，我们首先使用蒙特卡罗模拟成像数据，其中地面真相是已知的定量比较。然后，我们证明了八套临床采集，其中的主题表现出不同程度的呼吸运动模糊所提出的方法。定量评价结果表明，4D重建与呼吸校正可以有效地减少运动模糊的影响，导致更准确的心肌重建。心肌的均方误差降低了22%，LV分辨率提高了21%。临床采集也证明了这种改善，其中重建的左心室壁和血池中的运动模糊显着改善。还注意到所提出的方法对校正来自附近肠或肝活动的心肌中的溢出效应是有效的。
Cardiac SPECT images are known to suffer from both cardiac and respiratory motion blur. In this work, we investigate a 4D reconstruction approach to suppress the effect of respiratory motion in gated cardiac SPECT imaging. In this approach, the sequence of cardiac gated images is reconstructed with respect to a reference respiratory amplitude bin in the respiratory cycle. To combat the challenge of inherent high imaging noise, we utilize the data counts acquired during the entire respiratory cycle by making use of a motion-compensated scheme, in which both cardiac motion and respiratory motion are taken into account. In our evaluation study, we first use Monte Carlo simulated imaging data wherein the ground truth is known for quantitative comparison. We then demonstrate the proposed approach on eight sets of clinical acquisitions, in which the subjects exhibit different degrees of respiratory motion blur. The quantitative evaluation results show that 4D reconstruction with respiratory correction could effectively reduce the effect of motion blur and lead to a more accurate reconstruction of the myocardium. The mean-squared-error of the myocardium is reduced by 22%, and the LV resolution is improved by 21%. Such improvement is also demonstrated with the clinical acquisitions, where the motion blur is markedly improved in the reconstructed LV wall and blood pool. The proposed approach is also noted to be effective on correcting the spill-over effect in the myocardium from nearby bowel or liver activities.