The sexual health of female rectal and anal cancer survivors: results of a pilot randomized psycho-educational intervention trial.
The sexual health of female rectal and anal cancer survivors: results of a pilot randomized psycho-educational intervention trial.
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DOI：
10.1007/s11764-015-0501-8
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Carter J
中科院分区：
文献类型：
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作者：
DuHamel K;Schuler T;Nelson C;Philip E;Temple L;Schover L;Baser RE;Starr TD;Cannon K;Jennings S;Jandorf L;Carter J
性功能障碍是直肠/肛门癌治疗女性患者的常见后果。本研究的目的是进行一项小型随机对照试验，以评估电话为基础的四期癌症幸存者性健康干预（CSI-SH）的疗效。在随机分配到CSI-SH或仅评估（AO）之前，根据化疗、造口和绝经状态对参与者（N = 70）进行分层。在基线、4个月（随访1）和8个月（随访2）时对参与者进行评估。干预措施从基线到随访1的效应量中等，随访2的效应量下降。41名性活跃女性的效应值更大。未调整的随访平均值在治疗组之间没有显著差异。调整基线评分、人口统计学和医学变量后，干预组在随访1和2时的情绪功能明显更好，随访1时的癌症特异性压力也比AO组少。与AO相比，这些数据支持了CSI-SH女性直肠癌/肛门癌幸存者在改善性和心理功能以及生活质量方面的假设作用。这项CSI-SH的试点研究（N = 70）支持与AO条件相比，该干预对直肠和肛门癌幸存者的性和心理功能以及生活质量的影响。然而，与随访2相比，干预效果在随访1中更强，对性活跃的女性更强。在直肠癌和肛门癌治疗后，妇女可能受益于一次简短的四次性健康干预。
Sexual dysfunction is a frequently reported consequence of rectal/anal cancer treatment for female patients. The purpose of this study was to conduct a small randomized controlled trial to assess the efficacy of a telephone-based, four-session Cancer Survivorship Intervention-Sexual Health (CSI-SH). Participants (N = 70) were stratified by chemotherapy, stoma, and menopause statuses before randomization to CSI-SH or assessment only (AO). Participants were assessed at baseline, 4 months (follow-up 1), and 8 months (follow-up 2). The intervention had medium effect sizes from baseline to follow-up 1, which decreased by follow-up 2. Effect sizes were larger among the 41 sexually active women. Unadjusted means at the follow-ups were not significantly different between the treatment arms. Adjusting for baseline scores, demographics, and medical variables, the intervention arm had significantly better emotional functioning at follow-ups 1 and 2 and less cancer-specific stress at follow-up 1 compared to the AO arm. The data supported the hypothesized effects on improved sexual and psychological functioning and quality of life in CSI-SH female rectal/anal cancer survivors compared to the AO condition. This pilot study (N = 70) of CSI-SH supported the impact of this intervention on sexual and psychological functioning and quality of life on rectal and anal cancer survivors compared with an AO condition. However, intervention effects were stronger at follow-up 1 as compared to follow-up 2 and were stronger for sexually active women. Women may benefit from a brief, four-session, sexual health intervention after treatment from rectal and anal cancer.