BISPYRIDINAMINES - A NEW CLASS OF TOPICAL ANTIMICROBIAL AGENTS AS INHIBITORS OF DENTAL PLAQUE
BISPYRIDINAMINES - A NEW CLASS OF TOPICAL ANTIMICROBIAL AGENTS AS INHIBITORS OF DENTAL PLAQUE
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DOI：
10.1021/jm00377a014
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发表时间：
1984-01-01
影响因子：
7.3
通讯作者：
SLEE, AM
中科院分区：
文献类型：
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作者：
BAILEY, DM;DEGRAZIA, CG;SLEE, AM
合成了一系列N，N“-聚亚烷基双[4-（取代氨基）吡啶]，并评价了其作为潜在的抗牙菌斑剂的性能。从该系列中最具活性的成员中，选择了一种化合物，N，-N“-[1，10-癸二基二-1（4 H）-吡啶基-4-亚基]双（1-辛胺）二盐酸盐，奥替尼啶，作为临床研究的候选药物。[变形链球菌是试验微生物。]。
A series of N,N''-polyalkylenebis[4-(substituted-amino)pyridines] was prepared, and members were evaluated as potential anti-dental plaque agents. From among the most active members of the series, one compound, N,-N''-[1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene]bis(1-octanamine) dihydrochloride, octenidine, was selected as a candidate for clinical study. [Streptococcus mutans was the test organism.].