Specific nuclear triiodothyronine binding sites in rat liver and kidney.
Specific nuclear triiodothyronine binding sites in rat liver and kidney.
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大鼠肝脏和肾脏中特定的核三碘甲状腺原氨酸结合位点。
DOI：
10.1210/jcem-35-2-330
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
M. Surks
中科院分区：
文献类型：
--
作者：
J. Oppenheimer;D. Koerner;H. L. Schwartz;M. Surks
摘要：大鼠肝、肾细胞中，随着L-三碘甲腺原氨酸（T3）剂量的增加，T3与细胞核结合的比例逐渐降低。对于其他超中性半乳糖组分，无法证明类似的剂量-反应关系。在注射大量碘甲腺原氨酸后，只观察到甲状腺素的核结合适度减少。结果表明，在大鼠肝、肾细胞核中存在T3的相对特异性结合位点。
ABSTRACT Injection of increasing quantities of L-triiodothyronine (T3) resulted in a progressive decrease in the proportion of T3 bound to the nuclear fraction of rat liver and kidney cells. A similar dose-response relationship could not be demonstrated for other ultracentrifugal fractions. Only a modest reduction in nuclear binding of thyroxine was observed after injection of large amounts of this iodothyronine. The results indicate the presence of relatively specific binding sites for T3 in the nuclei of rat liver and kidney.