Sensitization of group III muscle afferents to static contraction by arachidonic acid.
Sensitization of group III muscle afferents to static contraction by arachidonic acid.
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III 组肌肉传入对花生四烯酸静态收缩的敏感性。
DOI：
10.1152/jappl.1990.68.3.861
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Kaufman,MP
中科院分区：
文献类型：
--
作者：
Rotto,DM;Schultz,HD;Longhurst,JC;Kaufman,MP
反射的传入臂负责对静态收缩的升压反应，由 III 组和 IV 纤维组成。激活这些纤维的收缩诱导刺激的性质仍不清楚。有证据表明，大多数 III 组传入神经对机械刺激敏感，而大多数 IV 组传入神经对代谢刺激敏感。最近，在麻醉猫中，第三组机械感受器的刺激已被证明在静态收缩的反射性升压反应中起作用。在皮肤中，花生四烯酸代谢的环氧合酶和脂氧合酶产物已证明细纤维机械感受器对其感受野变形的敏感性增加。因此，在巴比妥麻醉的猫中，我们记录了在花生四烯酸（1-2 mg ia）和/或吲哚美辛（5 mg/kg iv）之前和之后第 III 组肌肉传入神经对静态收缩的反应。花生四烯酸使第 III 组传入神经 (n = 11) 对收缩的反应增加了 265%（从 0.17 +/- 0.07 到 0.62 +/- 0.24 脉冲/秒；P 小于 0.025）。吲哚美辛使第 III 组传入神经 (n = 9) 对收缩的反应降低了 61%（从 1.00 +/- 0.37 到 0.39 +/- 0.16 脉冲/秒；P 小于 0.025）。吲哚美辛后给予花生四烯酸增加了四个 III 组传入神经中的两个对收缩的反应。我们得出的结论是，花生四烯酸代谢的环氧合酶和脂氧合酶产物均使第 III 组肌肉传入神经对静态收缩敏感。
The afferent arm of the reflex are responsible for the pressor response to static contraction is comprised of group III and IV fibers. The nature of the contraction-induced stimulus activating these fibers remains unclear. Evidence suggests that most group III afferents are sensitive to mechanical stimuli, whereas most group IV afferents are sensitive to metabolic stimuli. Recently, in anesthetized cats, stimulation of group III mechanoreceptors has been shown to have a role in the reflex pressor response to static contraction. In skin, the sensitivity of thin fiber mechanoreceptors to distortion of their receptive fields has been shown to be increased by both cyclooxygenase and lipoxygenase products of arachidonic acid metabolism. Therefore, in barbiturate-anesthetized cats we recorded the responses of group III muscle afferents to static contraction before and after arachidonic acid (1-2 mg ia) and/or indomethacin (5 mg/kg iv). Arachidonic acid increased the responses of group III afferents (n = 11) to contraction by 265% (from 0.17 +/- 0.07 to 0.62 +/- 0.24 impulses/s; P less than 0.025). Indomethacin decreased the responses of group III afferents (n = 9) to contraction by 61% (from 1.00 +/- 0.37 to 0.39 +/- 0.16 impulses/s; P less than 0.025). Arachidonic acid given after indomethacin increased the responses of two of four group III afferents to contraction. We conclude that both cyclooxygenase and lipoxygenase products of arachidonic acid metabolism sensitize group III muscle afferents to static contraction.