Knoevenagel condensation reaction catalyzed by task-specific ionic liquid under solvent-free conditions
Knoevenagel condensation reaction catalyzed by task-specific ionic liquid under solvent-free conditions
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DOI：
10.1016/j.catcom.2008.01.002
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发表时间：
2008-04
影响因子：
3.7
通讯作者：
Caibo Yue;Aiqin Mao;Yun-yang Wei;Minjie Lü
中科院分区：
文献类型：
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作者：
Caibo Yue;Aiqin Mao;Yun-yang Wei;Minjie Lü
合成了一种特定任务的离子液体[H3N+–CH2–CH2–OH][CH3COO−]，并用作各种芳香醛与氰基乙酸乙酯或丙二腈的Knoevenagel缩合反应的催化剂。当[H3N+–CH2–CH2–OH][CH3COO−]催化Knoevenagel反应在无溶剂条件下在室温下进行数至60分钟时，以合理的收率获得了α,β-不饱和羰基化合物。仅检测到E-异构体。去除水后的特定任务离子液体可以回收并重复使用五次而不会明显降低催化活性。讨论了[H3N+–CH2–CH2–OH][CH3COO−]催化Knoevenagel反应的机理。
A task-specific ionic liquid, [H3N+–CH2–CH2–OH][CH3COO−] was synthesized and used as catalyst in the Knoevenagel condensation reaction of various kinds of aromatic aldehydes with ethyl cyanoacetate or malononitrile. α,β-Unsaturated carbonyl compounds were obtained in reasonable yields when the [H3N+–CH2–CH2–OH][CH3COO−] catalyzed Knoevenagel reaction was carried out at room temperature for several to 60min under solvent-free conditions. Only E-isomers were detected. The task-specific ionic liquid after removed water could be recycled and reused for five times without noticeably decreasing the catalytic activity. The mechanism of the [H3N+–CH2–CH2–OH][CH3COO−] catalyzed Knoevenagel reaction was discussed.