c-Fos- and JunB-immunoreactivities in the enteric nervous system of the guinea-pig ileum.
c-Fos- and JunB-immunoreactivities in the enteric nervous system of the guinea-pig ileum.
复制标题
豚鼠回肠肠神经系统中的 c-Fos- 和 JunB- 免疫反应性。
DOI：
10.1097/00001756-199408150-00029
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发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Sharkey,KA
中科院分区：
文献类型：
--
作者：
Parr,EJ;Sharkey,KA
我们检测了c-Fos和JunB在豚鼠回肠四种免疫组织化学亚型肠神经元中的表达。分离的肌间神经丛和粘膜下神经丛在正常Krebs液中孵育的整体标本中，许多细胞表达可见的c-Fos和JunB免疫反应。这些增加可能与隔离和/或孵化条件的过程有关。藜芦碱或50 mM K+去极化刺激可引起神经元c-Fos和JunB表达进一步增加，但无明显的亚型偏爱。这可能反映了这些刺激对大多数肠神经元的非特异性激活，并支持了c-Fos和JunB在大多数或所有肠神经元中的表达可能是激活的有用决定因素的观点。
WE examined the expression of c-Fos and JunB in four immunohistochemical subtypes of enteric neurones in the guinea-pig ileum. In whole mount preparations of the myenteric and submucous plexuses from isolated segments incubated in normal Krebs' solution, increased numbers of many cells expressed visible c-Fos-and JunB-immunoreactivities. These increases may have been associated with the process of isolation and/or incubation conditions. Depolarizing stimulation by veratridine or 50 mM K+ induced further increases of neuronal c-Fos and JunB expression with no obvious subtype preference. This probably reflected a non-specific activation of most enteric neurones by these stimuli and supports the idea that expression of c-Fos and JunB in most or all enteric neurones may be a useful determinant of activation.