INTERICTAL CEREBRAL GLUCOSE-METABOLISM IN PARTIAL EPILEPSY AND ITS RELATION TO EEG CHANGES
INTERICTAL CEREBRAL GLUCOSE-METABOLISM IN PARTIAL EPILEPSY AND ITS RELATION TO EEG CHANGES
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DOI：
10.1002/ana.410120603
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发表时间：
1982-01-01
影响因子：
11.2
通讯作者：
MAZZIOTTA, JC
中科院分区：
文献类型：
--
作者：
ENGEL, J;KUHL, DE;MAZZIOTTA, JC
对50例部分性癫痫发作患者进行了发作间期正电子计算机断层扫描（PCT）和18F-氟脱氧葡萄糖。33例患者在代谢研究期间使用头皮和蝶骨电极进行脑电图（EEG）监测，17例患者在立体定向植入深部电极。该系列中有4例患者在X线计算机断层扫描中有局灶性异常，但仅2例位于假定的致癫痫病变部位。在35例患者中确定了一个或多个离散的低代谢区，只有1例患者显示局灶性发作间期高代谢。局灶性低代谢程度与发作间期EEG棘波频率或局灶性非癫痫性EEG变化之间无定量关系。得出的结论是，代谢和电生理技术测量不同方面的脑功能障碍的癫痫病。虽然部分性癫痫患者发作间期PCT通常表现为低代谢区，但这一发现并不能揭示异常的癫痫性质。
Interictal positron computed tomography (PCT) with18F‐fluorodeoxyglucose was performed on 50 patients with partial seizure disorders. Electroencephalographic (EEG) monitoring was carried out during the metabolic studies using scalp and sphenoidal electrodes in 33 patients and stereotaxically implanted depth electrodes in 17. Four patients in this series had focal abnormalities on x‐ray computed tomographic scans, but these were at the site of the presumed epileptogenic lesion in only 2. One or more discrete zones of hypometabolism were identified in 35 patients, and only 1 patient appeared to show focal interictal hypermetabolism. No quantitative relationship could be demonstrated between the degree of focal hypometabolism and either the frequency of intericatal EEG spikes or the presence of focal nonepileptifor EEg changes. It was concluded that metabolic and electrophysiological techniques measure different aspects of cerebral dysfunction in seizures diorders. Although interictal PCT in patients with partial epilepsy usually demonstrates zones of hypometabolism, this finding, perŕse, does not reveal the epileptic nature of the abnormality.