Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis.

Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis.
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随着时间的推移，草药大麻中的 Delta-9-四氢大麻酚 (Δ-9-THC) 含量不断增加：系统评价和荟萃分析。

DOI：
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发表时间：
2012
期刊：
Current Drug Abuse Reviews
影响因子：
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通讯作者：
G. D. Di Tanna
G. D. Di Tanna
中科院分区：
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文献类型：
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作者：
F. Cascini;C. Aiello;G. D. Di Tanna

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目的 这项荟萃分析的目的是评估大麻草药效力随时间变化的数据（1970年至2009年）。 方法 对17个电子科学数据库的系统搜索确定了关于这一主题的研究，其中21个病例系列研究符合我们的纳入标准，即报告每年每样本数的平均四氢大麻酚（THC）值。没有语言、出版日期、出版类型或地位的限制。研究选择和数据提取过程由两位作者独立但统一进行，包括筛选，确定合格性和将合格研究纳入系统性综述，以及对草药大麻样品中THC含量结果的荟萃分析。我们考虑的是论文而不是专题科学出版物，拒绝了所有不关注本综述主题的研究。 结果 使用随机效应模型对21项研究进行了年度荟萃分析，其中包含1979年至2009年的75项THC观察结果。结果显示，研究之间存在很大差异。此外，在草药大麻中，年份和平均THC之间存在显著相关性。综合数据表明，草药大麻中的年和平均THC之间存在相关性，揭示了效力增加的时间趋势（在泊松回归分析中高于平均THC值5%）。 结论 分析结果表明，最近全世界大麻的效力一直在增加。
AIM The objective of this meta-analysis is to assess the data regarding changes in herbal cannabis potency over time (from 1970 to 2009). METHODS Systematic searches of 17 electronic scientific databases identified studies on this topic, within which 21 case series studies satisfied our inclusion criteria of reporting the mean tetrahydrocannabinol (THC) value per number of samples per year. No language, publication date, publication type or status restrictions were imposed. The study selection and data extraction processes were performed independently but uniformly by two authors, included screening, determination of eligibility and inclusion of the eligible studies in the systematic review, and a meta-analysis of the results on THC content in herbal cannabis samples. We considered papers and not monographic scientific publications, rejecting all studies that were not focused on the subject of this review. RESULTS Meta-analysis by year was performed on 21 studies containing 75 total mean THC observations from 1979 to 2009 using the random effects model. The results revealed much variability between studies. Further, there was a significant correlation between year and mean THC in herbal cannabis. The combined data indicated the correlation between year and mean THC in herbal cannabis, revealing a temporal trend of increasing potency (5% above the mean THC value in the Poisson regression analysis). CONCLUSIONS The results of the analysis suggest that there has been a recent and consistent increase in cannabis potency worldwide.