Effect of changes in end-tidal carbon dioxide tension on oral tissue blood flow during dexmedetomidine infusion in rabbits
Effect of changes in end-tidal carbon dioxide tension on oral tissue blood flow during dexmedetomidine infusion in rabbits
复制标题
右美托咪定输注时家兔呼气末二氧化碳张力变化对口腔组织血流的影响
DOI：
10.1111/eos.12162
复制
发表时间：
2015
影响因子：
1.9
通讯作者：
Ichinohe T
中科院分区：
文献类型：
--
作者：
Okada R;Matsuura N;Kasahara M;Ichinohe T
全身麻醉时动脉二氧化碳张力的降低引起咬肌血流量的增加和下颌骨髓血流量的减少。此外，右美托咪定输注可减少口腔组织血流量。在这项研究中，我们研究了在连续右美托咪定输注过程中，尾潮二氧化碳张力（ET - CO2）变化对兔口腔组织血流的影响。用七氟醚麻醉11只雄性日本大白兔。然后，将ET - co2设定为30 mmHg，调整为40和60 mmHg，测量心率、收缩压、舒张压、平均动脉压、颈总动脉血流量、下颌骨髓血流量、咬肌血流量和其他口腔组织血流量。随后，ET - co2恢复到30 mmHg，右美托咪定输注超过60分钟。重复测量。无论是否使用右美托咪定，大多数参数都增加了，心率和咬肌血流量以ET - CO2依赖的方式减少。右美托咪定输注抑制ET - CO2依赖性咬肌血流变化。使用右美托咪定治疗ET - CO2at 30 mmHg时咬肌血流量与不使用右美托咪定治疗ET - CO2at 40 mmHg时相同。我们的研究结果表明，右美托咪定输注和全身麻醉下轻度低碳酸血症抑制咬肌血流量的增加，并减少下颌骨髓血流量。这些结果对减少口腔颌面外科手术出血有一定的指导意义。
A decrease in arterial carbon dioxide tension induces an increase in masseter muscle blood flow and a decrease in mandibular bone marrow blood flow during general anesthesia. In addition, dexmedetomidine infusion reduces oral tissue blood flow. In this study we investigated how end‐tidal carbon dioxide tension (ET‐CO2) changes influence on oral tissue blood flow during continuous dexmedetomidine infusion in rabbits. Eleven male Japan White rabbits were anesthetized with sevoflurane. Then, ET‐CO2was set at 30 mmHg and adjusted to 40 and 60 mmHg, and heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, common carotid artery blood flow, mandibular bone marrow blood flow, masseter muscle blood flow, and blood flow in other oral tissues were measured. Following this, the ET‐CO2was returned to 30 mmHg and dexmedetomidine was infused over 60 min. The measurements were repeated. Most parameters increased, regardless of whether or not dexmedetomidine was present, and heart rate and masseter muscle blood flow decreased in an ET‐CO2‐dependent manner. Dexmedetomidine infusion suppressed ET‐CO2‐dependent masseter muscle blood flow change. Masseter muscle blood flow during ET‐CO2at 30 mmHg with dexmedetomidine was the same as that during ET‐CO2at 40 mmHg without dexmedetomidine. Our findings suggest that dexmedetomidine infusion and slight hypocapnia under general anesthesia suppress an increase in masseter muscle blood flow as well as reducing mandibular bone marrow blood flow. These results may be of significance for decreasing bleeding during oral and maxillofacial surgery.