Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females
Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females
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DOI：
10.1007/s00198-004-1656-8
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发表时间：
2005-01-01
影响因子：
4
通讯作者：
Cromer, B
中科院分区：
文献类型：
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作者：
Harkness, L;Cromer, B
本研究旨在探讨北方地区青春期女性中25-羟基维生素D[25(OH)D]与甲状旁腺激素(PTH)水平的关系。这一人群对维生素D状况的担忧是由于北纬地区阳光照射有限，户外娱乐活动减少，以及黑人女孩皮肤色素沉着增加而转化为维生素D的减少。在这项横断面分析中，血清样本采用竞争性蛋白结合(CPB)法检测25(OH)D，甲状旁腺素(PTH)采用免疫放射分析(RIA)法检测。招募了400名居住在俄亥俄州东北部的初潮后女性(12-18岁)。如果受试者有骨骼、肾脏病史，则排除在外。或肝脏疾病，或使用影响骨骼的药物。主要目的是确定青春期女孩群体中血清25(OH)D浓度与循环甲状旁腺素水平的关系。用Spearman相关检验比较甲状旁腺素和25(OH)D，用拟合复分裂模型确定25(OH)D和甲状旁腺素作图时回归线的斜率变化。在最终模型中，通过种族和季节的差异，使用建模方法来确定方差分析。未调整前血清25(OH)D和PTH水平分别为55.0+/-30.4nmol/L和39.4+/-20.6 ng/L。黑人25(OH)D低于非黑人，甲状旁腺素高于非黑人(P
This study aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH)D)] and parathyroid hormone (PTH) levels in adolescent females residing in a northern climate. Concern regarding vitamin D status in this population is due to limited sunlight exposure in northern latitudes, decreased outdoor recreational activities, as well as decreased conversion in black girls from increased skin pigmentation. In this cross-sectional analysis, serum samples were assayed for 25(OH)D using competitive protein binding (CPB) assay and PTH with immuno-radiometric (RIA) procedures. Four hundred postmenarcheal females (12-18 years) residing in northeastern Ohio were recruited. Subjects were excluded if they had a history of bone, kidney.. or liver disease, or used medications that affect bone. The primary goal was to determine serum 25(OH)D concentrations in relation to circulating PTH levels in a population of adolescent girls. The Spearman correlation test was used to compare PTH and 25(OH)D. Fit multiple split models were run to determine change in slope of the regression line when 25(OH)D and PTH were plotted. Analysis of variance was determined using modeled means with differences by race and season in the final model. Unadjusted mean serum 25(OH)D and PTH levels were 55.0 +/- 30.4 nmol/l and 39.4 +/- 20.6 ng/l, respectively. Blacks had lower 25(OH)D and higher PTH compared with non-blacks (P