Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
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DOI：
10.1016/j.biopsych.2006.09.040
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发表时间：
2007-08-01
影响因子：
10.6
通讯作者：
van Engeland, Herman
中科院分区：
文献类型：
--
作者：
Langen, Marieke;Durston, Sarah;van Engeland, Herman
背景：孤独症是由三个症状群定义的，包括重复和刻板行为。先前的研究表明基底神经节与这些行为有关。早期研究自闭症基底神经节的研究包括已知影响基底神经节体积的神经抑制剂的受试者。因此，我们调查了这些结构在药物的幼稚科目与autosit.Methods：体积磁共振测量的尾状核，壳核，和丘脑核进行了比较，在两个独立的样本的药物幼稚的，高功能的受试者与自闭症或Barger综合征：1）21名受影响的儿童和青少年和21名匹配的对照组; 2）21例青少年和21例正常对照组。校正后，这一结果仍然显着的总brain volume.Conclusions：这些结果牵连尾状核在自闭症，作为一个扩大的结构是不成比例的增加，在两个独立的样本的药物-天真的自闭症患者的总脑容量。
Background: Autism is defined by three symptom clusters, including repetitive and stereotyped behavior. Previous studies have implicated basal ganglia in these behaviors. Earlier studies investigating basal ganglia in autism have included subjects on neuroleptics known to affect basal ganglia volumes. Therefore, we investigated these structures in medication-naive subjects with autism.Methods: Volumetric magnetic resonance measures of caudate, putamen, and nucleus accumbens were compared in two independent samples of medication-naive, high-functioning subjects with autism or Asperger syndrome: 1) 21 affected children and adolescents and 21 matched control subjects; and 2) 21 affected adolescents and young adults and 21 matched control subjects.Results: Caudate nucleus was enlarged in both samples. This result remained significant after correction for total brain volume.Conclusions: These results implicate caudate nucleus in autism, as an enlargement of this structure was disproportional to an increase in total brain volume in two independent samples of medication-naive subjects with autism.