Fasting serum glucose level and cancer risk in Korean men and women
Fasting serum glucose level and cancer risk in Korean men and women
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DOI：
10.1001/jama.293.2.194
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发表时间：
2005-01-12
影响因子：
120.7
通讯作者：
Samet, JM
中科院分区：
文献类型：
--
作者：
Jee, SH;Ohrr, H;Samet, JM
糖尿病是一种严重且昂贵的疾病，在许多国家越来越普遍。糖尿病作为癌症危险因素的作用尚不清楚。目的研究韩国男性和女性空腹血糖和糖尿病与所有癌症和特定癌症风险之间的关系。设计，设置，1298385名韩国人的十年前瞻性队列研究（829770名男性和468615名女性），年龄30至95岁，从国家健康保险公司获得健康保险，并在1992-1995年进行了两年一次的医疗评估（随访长达10年）。主要结果测量癌症死亡和登记记录的事件癌症或癌症入院治疗。结果在10年的随访中，有20566例男性癌症死亡和5907例女性癌症死亡。使用考克斯比例风险模型并控制吸烟和饮酒，空腹血糖最高的分层（大于或等于140 mg/dL [大于或等于7.8 mmol/L]）的所有癌症合并死亡率较高（男性风险比[HR]，1.29; 95%置信区间[CI]，1.22-1.37;女性风险比[HR]，1.23; 95% CI，1.09-1.39）与最低水平分层（
Context Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear.Objective To examine the relationship between fasting serum glucose and diabetes and risk of all cancers and specific cancers in men and women in Korea.Design, Setting, and Participants Ten-year prospective cohort study of 1298 385 Koreans (829770 men and 468615 women) aged 30 to 95 years who received health insurance from the National Health Insurance Corp and had a biennial medical evaluation in 1992-1995 (with follow-up for up to 10 years).Main Outcome Measures Death from cancer and registry-documented incident cancer or hospital admission for cancer.Results During the 10 years of follow-up, there were 20566 cancer deaths in men and 5907 cancer deaths in women. Using Cox proportional hazards models and controlling for smoking and alcohol use, the stratum with the highest fasting serum glucose (greater than or equal to140 mg/dL [greater than or equal to7.8 mmol/L]) had higher death rates from all cancers combined (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.22-1.37 in men and HR, 1.23; 95% Cl, 1.09-1.39 in women) compared with the stratum with the lowest level (