Effect of Increasing Pulse Phase Duration on Neural Responsiveness of the Electrically Stimulated Cochlear Nerve.
Effect of Increasing Pulse Phase Duration on Neural Responsiveness of the Electrically Stimulated Cochlear Nerve.
复制标题
增加脉冲持续时间对电刺激耳蜗神经神经反应性的影响。
DOI：
10.1097/aud.0000000000000876
复制
发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Warner C
中科院分区：
文献类型：
--
作者：
He S;Xu L;Skidmore J;Chao X;Riggs WJ;Wang R;Vaughan C;Luo J;Shannon M;Warner C
This study aimed to 1) investigate the effects of increasing the pulse phase duration (PPD) on the neural response of the electrically-stimulated cochlear nerve (CN) in children with cochlear nerve deficiency (CND), and 2) compare the results from the CND population to those measured in children with normal-sized CNs. Study participants included 30 children with CND and 30 children with normal-sized CNs. All participants used a Cochlear™ Nucleus® device in the test ear. For each subject, electrically-evoked compound action potential (eCAP) input/output (I/O) functions evoked by single biphasic pulses with different PPDs were recorded at three electrode locations across the electrode array. PPD durations tested in this study included 50, 62, 75 and 88 μs/phase. For each electrode tested for each study participant, the amount of electrical charge corresponding to the maximum comfortable level measured for the 88 μs PPD was used as the upper limit of stimulation. The eCAP amplitude measured at the highest electrical charge level, the eCAP threshold (i.e., the lowest level that evoked an eCAP) and the slope of the eCAP I/O function were measured. Generalized Linear Mixed effect Models (GLMMs) with study group, electrode location and PPD as fixed effects and subject as the random effect were used to compare these dependent variables measured at different electrode locations and PPDs between children with CND and children with normal-sized CNs. Children with CND had smaller eCAP amplitudes, higher eCAP thresholds and smaller slopes of the eCAP I/O function than children with normal-sized CNs. Children with CND who had fewer electrodes with a measurable eCAP showed smaller eCAP amplitudes and flatter eCAP I/O functions than children with CND who had more electrodes with eCAPs. Increasing the PPD did not show a statistically significant effect on any of these three eCAP parameters in the two subject groups tested in this study. For the same amount of electrical charge, increasing the PPD from 50 to 88 μs for a biphasic pulse with a 7 μs interphase gap did not significantly affect CN responsiveness to electrical stimulation in human CI users. Further studies with different electrical pulse configurations are warranted to determine whether evaluating the eCAP sensitivity to changes in the PPD can be used as a testing paradigm to estimate neural survival of the CN for individual CI users.
