Chinese Time Trade-Off Values for EQ-5D Health States
Chinese Time Trade-Off Values for EQ-5D Health States
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EQ-5D 健康状态的中国时间权衡值
DOI：
10.1016/j.jval.2014.05.007
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发表时间：
2014-07-01
期刊：
影响因子：
4.5
通讯作者：
Luo, Nan
中科院分区：
文献类型：
--
作者：
Liu, Gordon G.;Wu, Hongyan;Luo, Nan
目的：采用时间权衡法构建中国普通人群的三水平欧洲五维健康量表（EQ-5D-3L）社会价值集。方法：采用定额抽样方法，从北京、广州、沈阳、成都、南京五个城市抽取研究样本。使用修改后的健康测量和评估方案，直接从研究样本中得出EQ-5D-3L描述性系统定义的97种健康状态子集的效用值，每个受访者评估13种健康状态。基于个体和总体水平的计量经济学模型，估计了所有243种EQ-5D-3L健康状态的效用值。检查了使用不同模型规格的各种线性回归模型，以使用预定义的模型选择标准确定最佳模型。结果如下：N3模型的基础上普通最小二乘回归在总体水平上产生了最佳的模型拟合，平均绝对误差为0.020，7和0个国家的预测误差分别大于0.05和0.10，在绝对幅度。该模型通过了模型误设定（F = 2.7; P = 0.0509，Ramsey回归方程设定误差检验）、异方差性（chi（2）= 0.97; P = 0.3254，Breusch-Pagan/Cook-Weisberg检验）和残差正态性（chi（2）= 1.285; P = 0.5259，Jarque-Bera检验）检验。预测值的范围（-0.149至0.887）与其他国家的估计值相似。结论：本研究采用时间权衡法成功建立了中国人EQ-5D-3L健康状态的效用值。这是中国首次尝试开发量化质量调整生命年的标准化工具。
Objective: To generate a Chinese general population based three-level EuroQol five-dimensios (EQ-5D-3L) social value set using the time trade-off method. Methods: The study sample was drawn from five cities in China: Beijing, Guangzhou, Shenyang, Chengdu, and Nanjing, using a quota sampling method. Utility values for a subset of 97 health states defined by the EQ-5D-3L descriptive system were directly elicited from the study sample using a modified Measurement and Valuation of Health protocol, with each respondent valuing 13 of the health states. The utility values for all 243 EQ-5D-3L health states were estimated on the basis of econometric models at both individual and aggregate levels. Various linear regression models using different model specifications were examined to determine the best model using predefined model selection criteria. Results: The N3 model based on ordinary least square regression at the aggregate level yielded the best model fit, with a mean absolute error of 0.020, 7 and 0 states for which prediction errors were greater than 0.05 and 0.10, respectively, in absolute magnitude. This model passed tests for model misspecification (F = 2.7; P = 0.0509, Ramsey Regression Equation Specification Error Test), heteroskedasticity (chi(2) = 0.97; P = 0.3254, Breusch-Pagan/Cook-Weisberg test), and normality of the residuals (chi(2) = 1.285; P = 0.5259, Jarque-Bera test). The range of the predicted values (-0.149 to 0.887) was similar to those estimated in other countries. Conclusions: The study successfully developed Chinese utility values for EQ-5D-3L health states using the time trade-off method. It is the first attempt ever to develop a standardized instrument for quantifying quality-adjusted life-years in China.