Design, Synthesis, Bioactivity, and Structure-Activity Relationship (SAR) Studies of Novel Benzoylphenylureas Containing Oxime Ether Group
Design, Synthesis, Bioactivity, and Structure-Activity Relationship (SAR) Studies of Novel Benzoylphenylureas Containing Oxime Ether Group
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新型含肟醚基苯甲酰基苯基脲的设计、合成、生物活性和构效关系（SAR）研究
DOI：
10.1021/jf801901h
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发表时间：
2008-12-10
影响因子：
6.1
通讯作者：
Wang, Qingmin
中科院分区：
文献类型：
--
作者：
Sun, Ranfeng;Lue, Maoyun;Wang, Qingmin
采用四种方案设计合成了含肟醚基团的新型苯甲酰苯基脲类化合物。这些苯甲酰苯脲经核磁共振氢谱和元素分析（HRMS）鉴定。对新化合物的生物活性进行了评价。这些苯甲酰苯脲对东方粘虫具有良好的杀虫活性，其中部分活性优于市售氟环脲。其中化合物1和23对东方粘虫的杀幼虫活性比氟环虫脲强5 ~ 10倍。多数苯甲酰苯脲对蚊虫具有良好的杀幼虫活性。同时，其中一些化合物还具有良好的植物生长调节活性。
Novel benzoylphenylureas containing an oxime ether group were designed and synthesized by four schemes. These benzoylphenylureas were identified by H-1 NMR spectroscopy and element analysis (or HRMS). The bioactivities of the new compounds were evaluated. These benzoylphenylureas exhibited excellent larvicidal activities against oriental armyworm, some of which were much better in comparison with the commercial Flucycloxuron. In particular, the larvicidal activities against oriental armyworm of compounds 1 and 23 were 5-10 times better than that of Flucycloxuron. Most of these benzoylphenyureas exhibited excellent larvicidal activities against mosquito. At the same time, some of these compounds have good plant growth regulatory activities as well.