Social Support and Antibody Responses to Vaccination: A Meta-Analysis.
Social Support and Antibody Responses to Vaccination: A Meta-Analysis.
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疫苗接种的社会支持和抗体反应：荟萃分析。
DOI：
10.1093/abm/kaaa029
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Bolger,Niall
中科院分区：
文献类型：
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作者：
Uchino,BertN;Landvatter,Joshua;Zee,Katherine;Bolger,Niall
背景社会支持和社会融合与较低的发病率和死亡率有关。然而，需要更多地关注负责这种联系的生物机制。疫苗的范例提供了一个整合的窗口到免疫系统参与的保护性影响的社会支持/integration.PurposeThe本文的主要目的是社会支持/社会整合和抗体反应疫苗之间的关联进行荟萃分析审查。探索性分析还研究了效果大小和置信区间作为一个功能的几个因素，以告知未来的research.MethodA文献检索进行了使用的祖先的方法，并与PsycInfo，Medline，和心理学和行为科学收集交叉的确切关键字的社会支持或社会融合的疫苗或抗体。该审查确定了9项研究，共672 participators.ResultsThe综合荟萃分析表明，社会支持/社会融合与较高的抗体水平接种疫苗后，但平均效应大小是小的，置信区间的下限包括零（Zr= 0.06 [-0.04，.15]）。这些结果并没有出现不同的社会关系，参与者的年龄，或随访期间的操作功能，虽然效果大小出现较大的研究使用的主要antigen.ConclusionsThese数据提供了一些证据表明，社会支持可能与疫苗的抗体反应。然而，效应量大多很小，不能排除零总体效应。未来的研究将受益于更大的样本量和更多的考虑与抗原的二次免疫应答相关的方法学问题。
BackgroundSocial support and social integration have been linked to lower rates of morbidity and mortality. However, the biological mechanisms responsible for such links need greater attention. Vaccine paradigms provide an integrative window into immune system involvement in the protective influence of social support/integration.PurposeThe main aim of this article was to conduct a meta-analytic review of the association between social support/social integration and antibody responses to vaccines. Exploratory analyses also examined effect sizes and confidence intervals as a function of several factors to inform future research.MethodA literature search was conducted using the ancestry approach and with PsycInfo, Medline, and the Psychology and Behavioral Science Collection by crossing the exact keywords of social support or social integration with vaccine or antibodies. The review identified nine studies with a total of 672 participants.ResultsThe omnibus meta-analysis showed that social support/social integration was related to higher antibody levels following vaccination, but the average effect size was small and the lower bound of the confidence interval included zero (Zr= 0.06 [−.04, .15]). These results did not appear to differ much as a function of the operationalization of social relationships, participant age, or follow-up period, although effect sizes appeared larger for studies using a primary antigen.ConclusionsThese data provide some evidence that social support may be linked to antibody responses to vaccines. However, effect sizes are mostly small and zero overall effect cannot be ruled out. Future studies would benefit from larger sample sizes and greater consideration of methodological issues associated with secondary immune responses to antigen.