Prognostic Significance of Nestin Expression in Resected Non-small Cell Lung Cancer
Prognostic Significance of Nestin Expression in Resected Non-small Cell Lung Cancer
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DOI：
10.1378/chest.10-1121
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发表时间：
2011-04-01
期刊：
影响因子：
9.6
通讯作者：
Masuda, Noriyuki
中科院分区：
文献类型：
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作者：
Ryuge, Shinichiro;Sato, Yuichi;Masuda, Noriyuki
背景：巢蛋白是中枢神经系统发育过程中在干细胞/祖细胞中表达的 6 类中间丝蛋白。巢蛋白表达已在多种肿瘤中检测到，并在最近的一项针对非小细胞肺癌 (NSCLC) 的小规模研究中得到报道。我们研究了 Nestin 表达与临床病理参数之间的关系，并确定了其对切除的 NSCLC 患者生存的预后意义。方法：对 171 名连续 NSCLC 患者的肿瘤细胞中的 Nestin 表达进行免疫组织化学研究，并评估与临床病理参数的关联。采用Kaplan-Meier生存分析和Cox比例风险模型来评估Nestin表达对生存的影响。结果：171例NSCLC患者中有27例（15.8%）的肿瘤细胞样本中观察到Nestin表达。巢蛋白仅在细胞质中表达。临床病理学上，巢蛋白表达与鳞状细胞癌 (P=.001)、较差分化 (P=.007)、淋巴结转移 (P=.008)、瘤内血管侵犯 (P=.003)、瘤内淋巴管侵犯 (P=.008)、胸膜侵犯 (P=.039) 和较差预后 (P
Background: Nestin is a class 6 intermediate filament protein expressed in stem/progenitor cells during CNS development. Nestin expression has been detected in many kinds of tumors and was reported in a recent small-scale study in non-small cell lung cancer (NSCLC). We investigated the relationships between nestin expression and clinicopathologic parameters and determined its prognostic significance concerning survival in patients with resected NSCLC.Methods: Nestin expression in tumor cells was studied immunohistochemically in 171 consecutive patients with NSCLC, and associations with clinicopathologic parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of nestin expression on survival.Results: Nestin expression was observed in tumor cell samples in 27 of the 171 patients with NSCLC (15.8%). Nestin had only cytoplasmic expression. Clinicopathologically, nestin expression was significantly associated with squamous cell carcinoma (P=.001), poorer differentiation (P=.007), lymph node metastasis (P=.008), intratumoral vascular invasion (P=.003), intratumoral lymphatic invasion (P=.008), pleural invasion (P=.039), and poorer prognosis (P