Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans.
Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans.
复制标题
出汗时肌肉代谢感受器激活的调节和皮肤血管对人体核心温度升高的反应。
DOI：
10.1152/ajpregu.00005.2015
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kondo N.
中科院分区：
文献类型：
--
作者：
Amano T;Ichinose M;Inoue Y;Nishiyasu T;Koga S;Kondo N.
本研究通过测量与中枢和外周机制相关的被动加热过程中出汗和皮肤血管反应的核心温度阈值和斜率，研究了肌肉代谢物受体激活在人体体温调节中的作用。6名男性和8名女性受试者将他们的小腿插入热水(43摄氏度)，同时穿着上半身(34摄氏度)的灌水服。浸泡1min后，在对照组和实验条件下均进行等长握力练习--最大自主收缩的40%，持续1.5min，而运动后咬合仅在实验条件下进行9min。运动后被动加热时的前臂闭塞持续刺激肌肉代谢物受体，在整个实验期间平均动脉压显著升高(P<；0.05)。刺激前臂肌肉代谢物受体增加被动加热时的出汗和皮肤血管反应，并与食道出汗和皮肤血管扩张的温度阈值显著降低(Δ阈值，对照组和实验组分别为0.33±0.05和0.16±0.04°C，皮肤血管电导：0.38±0.08和0.16±0.05°C，P<；0.05)。这些反应的斜率在不同的条件下没有不同。这些结果表明，在被动加热过程中，前臂肌肉代谢物受体的激活加速了出汗和皮肤血管扩张，与核心温度阈值的降低有关，可能与控制热丢失反应的中枢机制有关。
The present study investigated the role of muscle metaboreceptor activation on human thermoregulation by measuring core temperature thresholds and slopes for sweating and cutaneous vascular responses during passive heating associated with central and peripheral mechanisms. Six male and eight female subjects inserted their lower legs into hot water (43°C) while wearing a water perfusion suit on the upper body (34°C). One minute after immersion, an isometric handgrip exercise—40% of maximum voluntary contraction—was conducted for 1.5 min in both control and experimental conditions, while postexercise occlusion was performed in the experimental condition only for 9 min. The postexercise forearm occlusion during passive heating consistently stimulated muscle metaboreceptors, as implicated by significantly elevated mean arterial blood pressure throughout the experimental period (P<0.05). Stimulation of the forearm muscle metaboreceptors increased sweating and cutaneous vascular responses during passive heating, and was associated with significant reductions in esophageal temperature threshold of sweating and cutaneous vasodilation (Δ threshold, sweating: 0.33 ± 0.05 and 0.16 ± 0.04°C, cutaneous vascular conductance: 0.38 ± 0.08 and 0.16 ± 0.05°C for control and experimental groups, respectively,P< 0.05). The slopes of these responses were not different between the conditions. These results suggest that muscle metaboreceptor activation in the forearm accelerates sweating and cutaneous vasodilation during passive heating associated with a reduction in core temperature thresholds and may be related to central mechanisms controlling heat loss responses.