The use of pencil lead as a matrix and calibrant for matrix-assisted laser desorption/ionisation
The use of pencil lead as a matrix and calibrant for matrix-assisted laser desorption/ionisation
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DOI：
10.1002/rcm.2408
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Herniman, J
中科院分区：
文献类型：
--
作者：
Black, C;Poile, C;Herniman, J
在基质辅助激光解吸/电离（MALDI）质谱分析中，铅笔芯被证明是一种有效的基质和校准剂。各种分析物，包括多肽、聚合物和锕系金属，当沉积在铅笔芯基体上时，可以很容易地使用MALDI电离。该基质在样品制备中具有优势，其疏水性和在分析过程中几乎完全抑制基质。用铅笔芯作基体是一种快速方便的定性分析方法，已被证明是锕系元素同位素比值分析的定量方法。(c) 2006年英国王室版权。经女王陛下文具办公室许可转载。约翰·威利父子有限公司出版。
Pencil lead is shown to be an effective matrix and calibrant in matrix-assisted laser desorption/ ionisation (MALDI) mass spectrometry. Various groups of analytes, including peptides, polymers and actinide metals, can be readily ionised using MALDI when deposited onto a pencil lead matrix. The matrix is seen to have advantages in sample preparation relating to its hydrophobic properties and almost complete suppression of the matrix during analysis. Using pencil lead as a matrix is a quick and convenient method of qualitative analysis and has been shown to be quantitative for the isotope ratio analysis of actinide metals. (c) Crown copyright 2006. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd.