INTRACELLULAR PH OF MITOGEN-STIMULATED LYMPHOCYTES
INTRACELLULAR PH OF MITOGEN-STIMULATED LYMPHOCYTES
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DOI：
10.1126/science.6281887
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
EUFE, W
中科院分区：
文献类型：
--
作者：
GERSON, DF;KIEFER, H;EUFE, W
Mitogenic [concanavalin A, bacterial lipopolysaccharide] stimulation of mouse lymphocytes results in 2 sequential intracellular alkalinizations. The 1st shift of intracellular pH from 7.18 to 7.35 coincides with early biochemical events following mitogenic stimulation. The 2nd alkalinization begins 12 h after stimulation and rises in parallel with the rate of thymidine incorporation. Intracellular alkalinization following stimulation may play a key role in the enhancement of cellular activation and mitogenesis.
