MUTATIONS IN T-CELL ANTIGEN RECEPTOR GENES ALPHA-BLOCK AND BETA-BLOCK THYMOCYTE DEVELOPMENT AT DIFFERENT STAGES
MUTATIONS IN T-CELL ANTIGEN RECEPTOR GENES ALPHA-BLOCK AND BETA-BLOCK THYMOCYTE DEVELOPMENT AT DIFFERENT STAGES
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DOI：
10.1038/360225a0
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发表时间：
1992-11-19
期刊：
影响因子：
64.8
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
MOMBAERTS, P;CLARKE, AR;TONEGAWA, S
对携带突变型T细胞抗原受体（TCR）基因的小鼠的分析表明，TCR-β基因重排或表达对于CD 4-CD 8-胸腺细胞向CD 4 + CD 8+胸腺细胞的分化以及对于CD 4 + CD 8+细胞库的扩增至关重要。TCR-alpha在这些发育过程中是无关紧要的。γ δ T细胞的发育不依赖于TCR-α或TCR-β。
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gammadelta T cells does not depend on either TCR-alpha or TCR-beta.