Regional white matter decreases in Alzheimer's disease using optimized voxel-based morphometry
Regional white matter decreases in Alzheimer's disease using optimized voxel-based morphometry
复制标题
使用优化的基于体素的形态测量法减少阿尔茨海默病的区域白质
DOI：
10.1080/02841850701627181
复制
发表时间：
2008-02-01
期刊：
影响因子：
1.3
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Li, Shuyu;Pu, Fang;Jiang, Tianzi
背景资料：大多数试图阐明阿尔茨海默病（AD）患者与功能断开相关的结构异常的研究都集中在探索皮质灰质的病理变化。然而，连接这些大脑区域的白色物质纤维也可能是abnormal.Purpose：探讨AD患者的白色物质体积的区域变化与健康subjects.Material和方法：白色物质体积的变化，从19例AD患者和20名健康受试者（对照组）获得的全脑磁共振图像使用优化的基于体素的形态测量（VBM）方法进行了观察。此外，AD患者和对照组的胼胝体（CC）进行了进一步的研究，通过手动勾勒的边界上的正中矢状切片的CC。CC的每个区域，然后通过划分每个主题的颅内面积在正中矢状planes.Results：与对照组相比，AD患者表现出显着减少白色物质体积的后部CC和颞叶在左，右半球。此外，在CC后部显示峰值统计学差异的体素位于左侧。CC的五个细分也显着较小的AD患者相对于对照组。结论：我们的研究结果表明，这些异常的白色物质区域可能有助于在AD的功能断开。
Background: Most studies that attempt to clarify structural abnormalities related to functional disconnection in patients with Alzheimer's disease (AD) have focused on exploring pathological changes in cortical gray matter. However, white matter fibers connecting these cerebral areas may also be abnormal.Purpose: To investigate the regional changes of white matter volume in patients with AD compared to healthy subjects.Material and Methods: White matter volume changes in whole-brain magnetic resonance images acquired from 19 patients with AD and 20 healthy subjects (control group) were observed using the optimized voxel-based morphometry (VBM) method. In addition, the corpus callosum (CC) of AD patients and the control group was investigated further by outlining manually the boundary of the CC on a midsagittal slice. Each area of the CC was then corrected by dividing each subject's intracranial area in the midsagittal plane.Results: Compared with the control group, AD patients showed significantly reduced white matter volumes in the posterior part of the CC and the temporal lobe in the left and right hemispheres. Moreover, the voxel showing peak statistical difference in the posterior of the CC was left sided. The five subdivisions of the CC were also significantly smaller among the AD patients relative to the control group.Conclusion: Our findings suggest that these abnormalities in white matter regions may contribute to the functional disconnections in AD.