Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study
Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study
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DOI：
10.1016/j.neures.2010.11.005
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发表时间：
2011-02-01
影响因子：
2.9
通讯作者：
Yamawaki, Shigeto
中科院分区：
文献类型：
--
作者：
Kunisato, Yoshihiko;Okamoto, Yasumasa;Yamawaki, Shigeto
最近，静息态功能磁共振成像（R-fMRI）引起了人们的兴趣，基于其检测默认模式网络的能力。我们研究了急性色氨酸耗竭（AM）对静息状态下低频波动分数振幅（fALFF）的影响，以及ATD后情绪变化与fALFF之间的相关性。我们操纵了21名右利手健康男性（平均年龄= 21.57 +/- 1.83岁）ATD后的中枢多巴胺能水平。采用受试者内、双盲、安慰剂对照和平衡设计。在AID或假耗竭后，受试者完成情绪状态（POMS）并进行5分钟R-fMRI扫描。我们的研究结果表明，ATD后中眶额皮质和楔前叶的fALFF明显减少，而上级顶叶、中央旁小叶和中央前回的fALFF明显增加。眶额皮质的fALFF与抑郁情绪呈负相关。顶叶上级小叶的fALFF与愤怒敌对性呈正相关，中央旁小叶的fALFF与活力活动性呈负相关。中眶额皮质在5-羟色胺缺乏引起的大脑变化和抑郁情绪变化的个体差异中起着关键作用。这些结果有助于进一步阐明缓解的MDD患者中ATD诱导复发的机制。(C)2010年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Recently, resting-state fMRI (R-fMRI) has attracted interest based on its ability to detect the default mode network. We examined the effect of acute tryptophan depletion (AM) on the fractional amplitude of low-frequency fluctuation (fALFF) during the resting state, and the correlation between changes of mood and fALFF following ATD. We manipulated the central serotonergic levels of 21 right-handed healthy males (mean age = 21.57 +/- 1.83 years) following ATD. A within-subjects, double-blind, placebo-controlled, and counter-balanced design was employed. Following AID or sham depletion, subjects completed the Profile of Mood States (POMS) and underwent 5-min R-fMRI scans. Our findings show that the fALFF of the middle orbitofrontal cortex and precuneus was significantly decreased and the fALFF of the superior parietal lobule, paracentral lobule and precentral gyrus was significantly increased after ATD. The fALFF of the orbitofrontal cortex was negatively correlated with depressive mood. The fALFF of the superior parietal lobule was positively correlated with anger-hostility and the fALFF of the paracentral lobule was negatively correlated with vigor-activity. The middle orbitofrontal cortex plays a key role in serotonin depletion-induced brain changes and individual differences in depressive mood change. These results serve to further elucidate the mechanism of ATD-induced relapse in remitted MDD patients. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.