Cross-sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001-2002.
Cross-sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001-2002.
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DOI：
10.1289/ehp.1510187
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发表时间：
2016-05
影响因子：
10.4
通讯作者：
Zota AR
中科院分区：
文献类型：
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作者：
Mitro SD;Birnbaum LS;Needham BL;Zota AR
暴露于持久性有机污染物（POP），如二恶英，呋喃和多氯联苯（PCB）可能会影响白细胞端粒长度（LTL），这是一种与慢性疾病相关的生物标志物。体外研究表明，二恶英可能与芳烃受体（AhR）结合，诱导端粒酶活性，从而延长LTL。然而，很少有流行病学研究调查持久性有机污染物和LTL之间的关联。我们研究了2001-2002年NHANES的1,330名美国成年人中18种多氯联苯、7种二恶英和9种呋喃与LTL之间的关系。我们根据毒性当量因子（TEF）创建了三个POP指标，毒性当量因子是一种包括AhR亲和力的效能度量：a）非二恶英类PCB（由10种非二恶英类多氯联苯组成;无AhR亲和力，无TEF）; B）非邻位多氯联苯（由2种非邻位取代的多氯联苯组成，具有高毒性当量系数）;毒性当量（TEQ）（由7种二恶英、9种呋喃、2种非邻位取代的多氯联苯和6种单邻位取代的多氯联苯组成;按毒性当量加权）。我们使用线性回归测试了每个指标和LTL之间的关联，调整了人口统计学，血细胞计数和分布，以及具有不同TEF的另一个指标（即，非邻位多氯联苯和针对非二恶英类多氯联苯调整的毒性当量;针对非邻位多氯联苯调整的非二恶英类多氯联苯）。在调整后的模型中，非邻位多氯联苯和毒性当量的血清浓度每增加一倍，LTL分别延长3.74%（95% CI：2.10，5.40）和5.29%（95% CI：1.66，9.05）。与最低四分位数相比，最高四分位数暴露分别与9.16%（95% CI：2.96，15.73）和7.84%（95% CI：-0.53，16.92）的LTL延长相关。非二恶英类多氯联苯与LTL无关。具有高TEF和AhR亲和力的持久性有机污染物与较长的LTL相关。由于许多二恶英相关的癌症也与较长的LTL，这些结果可能提供深入了解PCB和二恶英相关的致癌机制。Mitro SD，Birnbaum LS，Needham BL，Zota AR. 2016. 2001-2002年NHANES中美国成年人接触持久性有机污染物与白细胞端粒长度之间的横向关联。环境健康展望124：651-658; http：dx.doi.org/10.1289/ehp.1510187
Exposure to persistent organic pollutants (POPs) such as dioxins, furans, and polychlorinated biphenyls (PCBs) may influence leukocyte telomere length (LTL), a biomarker associated with chronic disease. In vitro research suggests dioxins may bind to the aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL. However, few epidemiologic studies have investigated associations between POPs and LTL. We examined the association between 18 PCBs, 7 dioxins, and 9 furans and LTL among 1,330 U.S. adults from NHANES 2001–2002. We created three summed POP metrics based on toxic equivalency factor (TEF), a potency measure including affinity for the AhR: a) non–dioxin-like PCBs (composed of 10 non–dioxin-like PCBs; no AhR affinity and no TEF); b) non-ortho PCBs (composed of 2 non–ortho-substituted PCBs with high TEFs); and c) toxic equivalency (TEQ) (composed of 7 dioxins, 9 furans, 2 non–ortho-substituted PCBs, and 6 mono–ortho-substituted PCBs; weighted by TEF). We tested the association between each metric and LTL using linear regression, adjusting for demographics, blood cell count and distribution, and another metric with a different TEF (i.e., non-ortho PCBs and TEQ adjusted for non–dioxin-like PCBs; non–dioxin-like PCBs adjusted for non-ortho PCBs). In adjusted models, each doubling of serum concentrations of non-ortho PCBs and TEQ was associated with 3.74% (95% CI: 2.10, 5.40) and 5.29% (95% CI: 1.66, 9.05) longer LTLs, respectively. Compared with the lowest quartile, the highest quartile of exposure was associated with 9.16% (95% CI: 2.96, 15.73) and 7.84% (95% CI: –0.53, 16.92) longer LTLs, respectively. Non–dioxin-like PCBs were not associated with LTL. POPs with high TEFs and AhR affinity were associated with longer LTL. Because many dioxin-associated cancers are also associated with longer LTL, these results may provide insight into the mechanisms underlying PCB- and dioxin-related carcinogenesis. Mitro SD, Birnbaum LS, Needham BL, Zota AR. 2016. Cross-sectional associations between exposure to persistent organic pollutants and leukocyte telomere length among U.S. adults in NHANES, 2001–2002. Environ Health Perspect 124:651–658; http://dx.doi.org/10.1289/ehp.1510187