TUMOR-TISSUE IS MORE SENSITIVE TO MITOMYCIN-C, CARBOQUONE, AND ACLACINOMYCIN-A THAN IS ADJACENT NORMAL TISSUE INVITRO
TUMOR-TISSUE IS MORE SENSITIVE TO MITOMYCIN-C, CARBOQUONE, AND ACLACINOMYCIN-A THAN IS ADJACENT NORMAL TISSUE INVITRO
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DOI：
10.1002/jso.2930400104
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发表时间：
1989-01-01
影响因子：
2.5
通讯作者：
SUGIMACHI, K
中科院分区：
文献类型：
--
作者：
MAEHARA, Y;KUSUMOTO, H;SUGIMACHI, K
采用体外琥珀酸脱氢酶抑制试验，检测了20例胃癌（15例胃癌，5例结直肠癌）和癌旁正常粘膜组织对丝裂霉素C（MMC）、卡波姆醌（CQ）和阿克拉霉素A（ACR）的敏感性。琥珀酸脱氢酶（SD）活性下降的程度更大，在肿瘤组织比在邻近的正常组织，在80%的MMC，80%的CQ，和90%的ACR。肿瘤与癌旁正常组织SD活性无相关性，MMC、CQ和ACR的SD活性分别为r=0.157、r=0.435和r=0.375。正常组织对MMC的敏感率为25%，CQ为46%，ACR为38%。结果表明，MMC、CQ和ACR的抗肿瘤作用对肿瘤组织有较强的特异性，正常组织的药敏试验对预测抗肿瘤药物对正常组织的毒性作用有一定意义。
In tissues obtained from patients undergoing gastrectomy or colectomy, sensitivity to mitomycin C (MMC), carboquone (CQ), and aclacinomycin A (ACR) was examined in 20 tumors (15 gastric, 5 colorectal) and in the adjacent normal mucosal tissues, using the in vitro succinate dehydrogenase inhibition test. The succinate dehydrogenase (SD) activity decreased to a greater extent in the tumor tissues than in adjacent normal tissues, at rates of 80% for MMC, 80% for CQ, and 90% for ACR. There were no correlations between SD activities of tumor and adjacent normal tissue, r=0.157 for MMC, r=0.435 for CQ, and r=0.375 for ACR. Normal tissues were sensitive to MMC in 25% of cases sensitive to MMC in the tumor tissues, 46% for CQ, and 38% for ACR. These results show that the antitumor effects of MMC, CQ, and ACR are relatively specific for tumor tissues and that the assay of chemosensitivity of normal tissues is meaningful for predicting the toxic effects of antitumor drugs on these tissues.