Preoperative peripheral blood lymphocyte-to-monocyte ratio is a prognostic indicator in oral squamous cell carcinoma: a retrospective study in a single institution
Preoperative peripheral blood lymphocyte-to-monocyte ratio is a prognostic indicator in oral squamous cell carcinoma: a retrospective study in a single institution
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DOI：
10.5794/jjoms.63.185
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Y. Watabe;K. Onidani;Nobuhiko Matsumoto;Kamichika Hayashi;T. Morikawa;Takeshi Onda;T. Yakushiji;H. Ohata;N. Takano;T. Shibahara
中科院分区：
文献类型：
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作者：
Y. Watabe;K. Onidani;Nobuhiko Matsumoto;Kamichika Hayashi;T. Morikawa;Takeshi Onda;T. Yakushiji;H. Ohata;N. Takano;T. Shibahara
尽管淋巴细胞与单核细胞比率（LMR）已被证明是多种癌症的预后指标，但术前LMR对口腔鳞状细胞癌患者的预后价值尚未有报道。本研究的目的是评估术前 LMR 是否可以预测口腔鳞状细胞癌患者的预后。我们研究了 2007 年 1 月至 2011 年 12 月期间在东京牙科学院千叶医院接受口腔鳞状细胞癌根治性手术的 210 名患者。LMR 根据术前外周血细胞计数计算。 LMR 的最佳截止点是根据总生存期的时间依赖性受试者工作特征曲线确定的。共有 94 名患者符合纳入标准。低 LMR 组的生存率显着低于高 LMR 组（p= 9.44 × 10-11，对数秩检验）。使用 Cox 比例风险模型的单变量分析表明，N 分类、疾病分期和治疗前 LMR 与不良结局显着相关。多变量分析显示，治疗前 LMR（风险比 [HR]：0.07；95% 置信区间 [CI]：0.01-0.37，p= 2.12 × 10-3）仍然是癌症相关死亡的危险因素。因此，治疗前 LMR 可能是口腔鳞状细胞癌患者的独立预后生物标志物。
Although lymphocyte-to-monocyte ratio (LMR) has been shown to be a prognostic indicator in various cancers, the prognostic value of preoperative LMR in patients with oral squamous cell carcinoma has not been reported. The aim of this study was to evaluate whether preoperative LMR could predict the outcomes of patients with oral squamous cell carcinoma. We studied 210 patients who underwent curative surgery for oral squamous cell carcinoma in Tokyo Dental College, Chiba Hospital between January 2007 and December 2011. LMR was calculated from the preoperative peripheral blood cell counts. The optimal cutoff point of LMR was determined on the basis of a time-dependent receiver operating characteristics curve for overall survival. A total of 94 patients met the inclusion criteria. The low LMR group had a significantly lower survival rate than the high LMR group (p= 9.44 × 10-11, log-rank test). Univariate analysis using a Cox proportional-hazards model showed that N classification, disease stage, and pretreatment LMR were significantly associated with poor outcomes. Multivariate analysis showed that pretreatment LMR (hazard ratio [HR] : 0.07; 95% confidence interval [CI] : 0.01-0.37, p= 2.12 × 10-3 ) remained as a risk factor for cancerrelated death. Thus, pretreatment LMR might be an independent prognostic biomarker in patients with oral squamous cell carcinoma.