The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories
The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories
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DOI：
10.1037/0735-7044.121.4.721
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发表时间：
2007-08-01
影响因子：
1.9
通讯作者：
Rudy, Jerry W.
中科院分区：
文献类型：
--
作者：
Matus-Amat, Patricia;Higgins, Emily A.;Rudy, Jerry W.
作者采用3时相背景预暴露易化方法，研究背海马（DH）和杏仁核基底外侧区（BLA）N-甲基-D-天冬氨酸（NMDA）受体对（a）背景记忆获得、（B）背景记忆提取、（c）背景-休克联想获得和（d）背景-休克联想提取的作用。NMDA受体拮抗剂D-2-氨基-5-膦酰基戊酸（D-AP 5）被注射到DH或BLA之前（a）的背景预暴露阶段，（B）立即休克阶段，或（c）测试的背景恐惧。拮抗DH中的NMDA受体损害了上下文记忆的获得，但不影响其检索或检索的恐惧记忆。拮抗NMDA受体与D-AP 5在BLA受损收购的上下文休克协会，但没有影响恐惧的表达。然而，在测试情境恐惧之前，当将DL-AP 5和L-AP 5注射到杏仁核中时，它们都减少了恐惧的表达。
The authors used 3-phase context preexposure facilitation methodology to study the contribution of N-methyl-D-aspartate (NMDA) receptors in dorsal hippocampus (DH) and the basal lateral region of the amygdala (BLA) to (a) acquisition of the context memory, (b) retrieval of the context memory, (c) acquisition of context-shock association, and (d) retrieval of the context-shock association. The NMDA receptor antagonist D-2-amino-5 phosphonopentanoic acid (D-AP5) was injected into either the DH or BLA prior to (a) the context preexposure phase, (b) the immediate shock phase, or (c) the test for contextual fear. Antagonizing NMDA receptors in the DH impaired the acquisition of the context memory but did not affect its retrieval or retrieval of the fear memory. Antagonizing NMDA receptors with D-AP5 in the BLA impaired acquisition of the context-shock association but had no effect on the expression of fear. However, both DL-AP5 and L-AP5 reduced the expression of fear when they were injected into the amygdala prior to testing for contextual fear.