The early wound signals.
The early wound signals.
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早期的伤口信号。
DOI：
10.1016/j.gde.2016.05.001
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发表时间：
2016-10
影响因子：
4
通讯作者：
Niethammer P
中科院分区：
文献类型：
--
作者：
Niethammer P
损伤组织屏障，如上皮细胞，会破坏体内平衡并导致感染。在几分钟内，动物就能检测到损伤，并通过募集吞噬细胞和关闭屏障来做出反应。激活这些第一反应的信号鲜为人知。通常被认为是通过裂解细胞将细胞质因子释放到细胞外空间(损伤相关分子模式，DAMPS)。DAMP通过模式识别受体激活转录。但仅靠转录机制很难解释伤口反应的快速性。这篇综述强调了非裂解应激信号在伤口快速检测中的作用。
Wounding of tissue barriers, such as epithelia, disrupts homeostasis and allows infection. Within minutes, animals detect injury and respond to it by recruitment of phagocytes and barrier breach closure. The signals that activate these first responses are scarcely known. Commonly considered are cytoplasmic factors released into the extracellular space by lysing cells (Damage Associated Molecular Patterns, DAMPs). DAMPs activate transcription through pattern recognition receptors. But the promptness of wound responses is difficult to explain by transcriptional mechanisms alone. This review highlights the emerging role of nonlytic stress signals in the rapid detection of wounds.