Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging
Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging
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DOI：
10.1148/radiol.2272020483
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发表时间：
2003-05-01
期刊：
影响因子：
19.7
通讯作者：
Bottomley, PA
中科院分区：
文献类型：
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作者：
Ouwerkerk, R;Bleich, KB;Bottomley, PA
目得：使用组合质子（H-1）和钠23（Na-23）磁共振（MR）成像，以非侵入性量化总组织钠浓度，并确定是否浓度改变恶性人脑tumors.MATERIALS和METHODS：绝对组织钠浓度恶性胶质瘤进行了测量，定量三维Na-23 MR图像与组织识别注册H-1 MR图像。在20例经病理证实的恶性脑肿瘤（星形细胞瘤，n = 17;少突胶质细胞瘤，n = 3）和9例健康志愿者的灰质（GM）、白色物质（WM）、脑脊液（CSF）和玻璃体液中测定浓度。根据Na-23图像信号强度确定肿瘤和水肿中的钠浓度，这些区域在T1加权H-1图像上为造影剂增强的区域（肿瘤）或在液体衰减反转恢复（FLAIR）H-1图像上仅为高信号的区域（水肿）。通过使用外部盐水溶液体模作为参考，从短回波时间（0.4 msec）获得的Na-23图像中无创测量钠浓度。采用配对t检验检验患者所有健康组织和病变的平均钠浓度差异。采用独立样本双尾t检验比较患者未受累组织和志愿者相同组织中的药物浓度。平均浓度（以毫摩尔/千克湿重计）为61 8（SD），GM为69 +/- 10，WM为135 +/-10，CSF为113 +/- 14，玻璃体液为103 +/- 36，肿瘤为103 +/- 36，未受影响的对侧组织为68 +/-11，肿瘤周围FLAIR高信号区为98 +/-12。显著性差异（P
PURPOSE: To use combined proton (H-1) and sodium 23 (Na-23) magnetic resonance (MR) imaging to noninvasively quantify total tissue sodium concentration and to determine if concentration is altered in malignant human brain tumors.MATERIALS AND METHODS: Absolute tissue sodium concentration in malignant gliomas was measured on quantitative three-dimensional Na-23 MR images with tissue identification from registered H-1 MR images. Concentration was determined in gray matter (GM), white matter (WM), cerebrospinal fluid (CSF), and vitreous humor in 20 patients with pathologically proven malignant brain tumors (astrocytoma, n = 17; oligodendroglioma, n = 3) and in nine healthy volunteers. Sodium concentration in tumors and edema was determined from Na-23 image signal intensities in regions that were contrast material enhanced on T1-weighted H-1 images (tumors) or regions that were only hyperintense on fluid-attenuated inversion recovery (FLAIR) H-1 images (edema). Sodium concentrations were measured noninvasively from Na-23 images obtained with short echo times (0.4 msec) by using external saline solution phantoms for reference. Differences in mean sodium concentration of all healthy tissue and lesions in patients were tested with a paired t test. Concentration in uninvolved tissues in patients was compared with that in the same tissue types in the volunteers with an independent samples two-tailed t test.RESULTS: Mean concentration (in millimoles per kilogram wet weight) was 61 8 (SD) for GM 69 +/- 10 for WM 135 +/- 10 for CSF 113 +/- 14 for vitreous humor 103 +/- 36 for tumor, 68 +/- 11 for unaffected contralateral tissue, and 98 +/-12 for FLAIR hyperintense regions surrounding tumors. Significant differences (P