A comparison of preference assessment instruments used in a clinical trial: Responses to the visual analog scale from the EuroQol EQ-5D and the health utilities index
A comparison of preference assessment instruments used in a clinical trial: Responses to the visual analog scale from the EuroQol EQ-5D and the health utilities index
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DOI：
10.1177/0272989x9901900305
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发表时间：
1999-07-01
影响因子：
3.6
通讯作者：
Schulman, KA
中科院分区：
文献类型：
--
作者：
Glick, HA;Polsky, D;Schulman, KA
目标.比较使用EuroQol EQ-5D和健康效用指数Mark II进行的偏好评估。科目甲磺酸替拉扎德治疗蛛网膜下腔出血的随机试验中的561例患者。措施随机化后3个月进行3次偏好评估（EuroQol工具的价值评分和健康效用指数的价值和效用评分）。根据临床结果和健康效用指数健康状态分类系统的属性，对三个评分中的每一个的平均值进行比较。为了评价工具之间差异的潜在来源，作者估计了两种替代的健康效用指数评分规则，这些规则基于患者对EuroQol工具的反应。结果使用EuroQol仪器的100分视觉模拟量表对患者当前健康状况进行的评分与健康效用指数的效用评分比健康效用指数的价值评分更相似。EuroQol工具的视觉模拟评分与健康效用指数的效用评分之间的最大差异见于较高水平的功能。结论对于代表较高功能水平的状态，通过使用EuroQol工具获得的患者自我评级与患者在健康效用指数上的效用评分之间存在差异;对于代表较低功能水平的状态，在这两个评分之间观察到实质性一致。在较高水平的功能中观察到的差异表明，需要进一步研究来确定健康效用指数将1.0分分配给代表健康的参考状态是否合适。
Objectives. To compare preference assessments that were made by using the EuroQol EQ-5D and the Health Utilities Index Mark II. Subjects. 561 patients in a randomized trial of tirilazad mesylate for aneurysmal subarachnoid hemorrhage. Measures. Three preference assessments (a value score for the EuroQol instrument and value and utility scores for the Health Utilities Index) made three months after randomization. The averages for each of the three scores, stratified by clinical outcomes and attributes of the Health Utilities Index health status classification system, were compared. To evaluate potential sources of difference between the instruments, the authors estimated two alternative Health Utilities Index scoring rules that were based on patient responses to the EuroQol instrument. Results. Patients' ratings of their current health made by using the 100-point visual analog scale from the EuroQol instrument were more similar to the utility scores for the Health Utilities Index than they were to the value scores for the Health Utilities index. The biggest differences between the visual analog scores for the EuroQol instrument and the utility scores for the Health Utilities index were seen at higher levels of functioning. Conclusion. For states representing higher levels of functioning, differences were seen between patients' self-ratings obtained by using the EuroQol instrument and the patients' utility scores on the Health Utilities Index; for states representing lower levels of functioning, substantial agreement was observed between these two scores. Differences observed at the higher levels of functioning suggest that further research is needed to determine whether the Health Utility Index's assignment of a score of 1.0 to the reference state representing being healthy is appropriate.