The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
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DOI：
10.1515/bc.2010.077
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发表时间：
2010-07-01
影响因子：
3.7
通讯作者：
Haeussinger, Dieter
中科院分区：
文献类型：
--
作者：
Keitel, Verena;Ullmer, Christoph;Haeussinger, Dieter
胆管细胞纤毛是一种感觉细胞器，从胆管顶端膜延伸到胆管腔，检测胆汁流量和渗透压的变化。胆管细胞纤毛是否对胆汁酸有反应尚不清楚。TGR5 （Gpbar-1）是一种膜结合胆汁酸受体，在胆道上皮细胞中表达，促进胆囊上皮细胞氯离子分泌。如本研究所示。TGR5定位于小鼠和人胆管细胞的原代纤毛。该受体在胆汁酸浓度和组成与胆管胆汁形成的耦合过程中发挥重要作用。
Cholangiocyte cilia are sensory organelles that extend from the apical membrane into the bile duct lumen and detect changes in bile flow and osmolarity. Whether or not cholangiocyte cilia are responsive to bile acids is unknown. TGR5 (Gpbar-1) is a membrane-bound bile acid receptor which is expressed in biliary epithelial cells and promotes chloride secretion in gallbladder epithelial cells. As shown in the present study. TGR5 is localized in the primary cilium of mouse and human cholangiocytes. Here the receptor could play an important role in coupling biliary bile acid concentration and composition to ductular bile formation.