Long-term immunity to measles, mumps and rubella after MMR vaccination among children with bone marrow transplants
Long-term immunity to measles, mumps and rubella after MMR vaccination among children with bone marrow transplants
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DOI：
10.1038/sj.bmt.1704476
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发表时间：
2004-06-01
影响因子：
4.8
通讯作者：
Grafakos, S
中科院分区：
文献类型：
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作者：
Spoulou, V;Giannaki, M;Grafakos, S
对30例骨髓移植患儿进行了麻疹、腮腺炎、风疹（MMR）疫苗诱导的长期免疫研究。MMR的基线免疫力分别为13.3%、33.3%和66.6%。MMR疫苗接种未能引起足够的和持久的反应，麻疹和腮腺炎，血清阳性率在1和12个月分别为26.6%和23.3%，腮腺炎46.6%和36.6%。相比之下，30名BMT儿童中有27名在免疫后1个月对风疹免疫，并在12个月时保持保护性抗体水平。在所有应答者中，MMR诱导的对风疹的回忆性应答与高亲和力抗体的产生相关。我们的结论是，单剂量的MMR给予2年后，骨髓移植诱导次优和短暂的免疫反应麻疹和腮腺炎，第二剂应建议儿科骨髓移植收件人。
Measles, mumps and rubella (MMR) vaccine-induced long-term immunity was studied in 30 children with bone marrow transplants (BMT). Immunity at baseline for MMR was 13.3, 33.3 and 66.6%, respectively. MMR vaccination failed to induce adequate and persistent responses to measles and mumps; seropositivity at 1 and 12 months for measles was 26.6 and 23.3% and for mumps 46.6 and 36.6%, respectively. In contrast, 27 of 30 children with a BMT were immune to rubella 1 month after immunization and retained protective antibody levels at 12 months. The MMR-induced anamnestic responses to rubella among all responders were associated with the production of high avidity antibodies. We conclude that a single dose of MMR given at 2 years after BMT induces suboptimal and short-lived immune responses to measles and mumps; a second dose should be recommended for paediatric BMT recipients.