Effect of the antioxidant action of ginkgo biloba extract (EGb 761) on aging and oxidative stress
Effect of the antioxidant action of ginkgo biloba extract (EGb 761) on aging and oxidative stress
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DOI：
10.1007/s11357-997-0013-1
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
DroyLefaix, MT
中科院分区：
文献类型：
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作者：
DroyLefaix, MT
衰老会对DNA、蛋白质、脂质和其他与组织改变相关的大分子造成氧化损伤，由此产生的损伤会显著导致退行性疾病，包括大脑、感觉组织和心血管系统的疾病。为了保护细胞成分免受氧自由基的攻击，特别是脂质过氧化，人们对抗氧化剂的使用产生了很大的兴趣，一种自由基清除剂，银杏叶提取物（EGb 761）可能有效地对抗与衰老有关的氧化应激。许多数据支持egb761在生物模型系统中的有效性。在衰老过程中，egb761可能通过猝灭超氧阴离子、羟基和过氧自由基来改善线粒体呼吸链功能。此外，在感觉组织中，EGb 761可减少嗅球和眼睛视网膜色素上皮的细胞凋亡，并防止视网膜的脂质过氧化改变，从而降低视网膜电图反应。在心血管系统中，EGb 761可直接作用于氧化性低密度脂蛋白。EGb 761可能会减缓动脉粥样硬化的演变，并被证明可以加速缺血-再灌注后的心脏机械恢复。综上所述，egb761在许多实验数据中的抗氧化作用，可能解释了在老年人临床试验中观察到的治疗效果。这些有益的特性似乎部分来自EGb 761成分的活性，如类黄酮和萜烯。
Aging is responsible for oxidative damage to DNA, protein, lipid, and other macromolecules linked to tissue alterations, The resultant damage contributes significantly to degenerative diseases, to include those of the brain, sensorial tissues, and cardiovascular system. To protect cellular components from oxyradical attack, especially lipoperoxidation, a substantial interest in the use of antioxidants has evolved, A free radical scavenger, Ginkgo biloba extract (EGb 761) may be effective in fighting the oxidative stress related to aging. Many data support the efficacy of EGb 761 in biological model systems. In aging processes, EGb 761 may ameliorate the mitochondria respiratory chain function by quenching the superoxide anion, and the hydroxyl and peroxyl radicals. It protects the brain by facilitating the uptake of neurotransmitters and by reducing ischemia-reperfusion episodes and level of apoptosis, Moreover, in sensorial tissues, EGb 761 reduces apoptosis in the olfactive bulb and in the retinal pigmented epithelium of the eye, and protects against the lipoperoxidation alteration of the retina that results in a decrease of the electroretinogram response, In the cardiovascular system, by a direct effect on oxidative low density lipoproteins, EGb 761 may decrease atherosclerosis evolution, and is shown to accelerate cardiac mechanical recovery after ischemia-reperfusion. In conclusion, the antioxidant effects of EGb 761 noted in many experimental data, may explain the therapeutic efficacy observed in clinical trials of the elderly. These beneficial properties seem in part to come from the activity of EGb 761 constituents, such as flavonoids and terpens.