Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain
Resilience after 9/11: Multimodal neuroimaging evidence for stress-related change in the healthy adult brain
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DOI：
10.1016/j.neuroimage.2007.12.010
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发表时间：
2008-04-01
期刊：
影响因子：
5.7
通讯作者：
Temple, Elise
中科院分区：
文献类型：
--
作者：
Ganzel, Barbara L.;Kim, Pilyoung;Temple, Elise
心理创伤是常见的，预示着长期的身体和精神健康问题，即使是那些最初表现出适应力的人。在此，我们对2001年9月11日距离世贸中心不同距离的健康成年人进行了多模态神经成像，以检查这种关联背后的神经机制。911事件后3年多，在年龄、性别和总灰质体积不受影响的情况下，离灾难更近的成年人杏仁核、海马、岛叶、前扣带和内侧前额叶皮层的灰质体积更低。进一步的分析表明，在整个组中，一生中创伤总数与杏仁核灰质体积和功能之间存在非线性（一阶二次）相关。对终生创伤暴露水平较高和较低的亚组进行的事后分析显示，杏仁核灰质体积、杏仁核功能反应性和焦虑之间存在系统关联，这表明健康成人对累积创伤的神经反应存在非线性轨迹(c) 2007 Elsevier Inc.)。版权所有。
Exposure to psychological trauma is common and predicts long-term physical and mental health problems, even in those who initially appear resilient. Here, we used multimodal neuroimaging in healthy adults who were at different distances from the World Trade Center on 9/11/01 to examine the neural mechanisms that may underlie this association. More than 3 years after 9/11/01, adults with closer proximity to the disaster had lower gray matter volume in amygdala, hippocampus, insula, anterior cingulate, and medial prefrontal cortex, with control for age, gender, and total gray matter volume. Further analysis showed a nonlinear (first-order quadratic) association between total number of traumas in lifetime and amygdala gray matter volume and function in the whole group. Post hoe analysis of subgroups with higher versus lower levels of lifetime trauma exposure revealed systematic associations between amygdala gray matter volume, amygdala functional reactivity, and anxiety that suggest a nonlinear trajectory in the neural response to accumulated trauma in healthy adults (c) 2007 Elsevier Inc. All rights reserved.