Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome: a case control study
Predictive value of ovarian stroma measurement for cardiovascular risk in polycyctic ovary syndrome: a case control study
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DOI：
10.1186/1757-2215-3-25
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发表时间：
2010-11-09
影响因子：
4
通讯作者：
Caringella, Anna Maria
中科院分区：
文献类型：
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作者：
Loverro, Giuseppe;De Pergola, Giovanni;Caringella, Anna Maria
背景：为了验证卵巢基质评估的可行性，并将卵巢参数（回声和体积）与高雄激素血症以及 PCOS 的心血管和代谢危险因素相关联。方法：纳入 24 名年轻 PCOS 患者和 12 名年龄匹配的对照女性。 PCOS 的诊断基于鹿特丹标准。超声卵巢研究包括卵巢体积、基质体积、基质面积和基质面积/总卵巢面积比（S/A）。关于激素，在卵泡早期（第 2-5 天）测量胰岛素、LH、FSH、雌二醇、雄烯二酮、睾酮、DHEAS、17-羟基孕酮和 SHBG。心血管危险因素以空腹血浆葡萄糖、血脂（总胆固醇和高密度脂蛋白胆固醇）、纤溶酶原激活剂抑制剂 1 (PAI-1)、血管性血友病因子 (vWF) 和脂联素的水平为代表。测量颈动脉内膜中层厚度 (C-IMT) 作为心血管风险的参数。结果：发现 S/A 比值与血浆睾酮 (p < 0.05) 和雄烯二酮 (p < 0.05) 水平呈正相关。 PCOS女性间质体积、间质面积和S/A比值也与PAI-1、vWF水平以及IMT呈显着正相关（P < 0.05）。结论：本研究表明卵巢间质超声测量是PCOS患者高雄激素血症程度、血栓前因素和心血管风险的预测因素。
Background: To verify the feasibility of ovarian stromal evaluation and correlate ovarian parameteres (echogenicity and volume) with hyperandrogenism, and both cardiovascular and metabolic risk factors in PCOS.Methods: Twenty four young PCOS patients and twelve age-matched control women were enrolled. Diagnosis of PCOS was based on the Rotterdam criteria. Ultrasound ovarian study included ovarian volume, stromal volume, stromal area and stromal area/total ovarian area ratio (S/A). Concerning hormones, insulin, LH, FSH, estradiol, androstenedione, testosterone, DHEAS, 17-hydroxy-progesterone, and SHBG were measured during the early follicular phase (days 2-5). Cardiovascular risk factors were represented by fasting plasma levels of glucose, lipids (total and HDL-cholesterol), plasminogen activator inhibitor 1 (PAI-1), von-Willebrand factor (vWF), and adiponectin. Carotid intima-media thickness (C-IMT) was measured as a parameter of cardiovascular risk.Results: A positive correlation between the S/A ratio and plasma levels of testosterone (p < 0.05) and androstenedione (p < 0.05) was found. The stromal volume, stromal area and S/A ratio were also significantly and positively correlated with PAI-1, and vWF levels, and with IMT in PCOS women (P < 0.05).Conclusions: This study shows that the ultrasound measurement of ovarian stroma is a predicting factor of hyperandrogenism degree, prothrombotic factors and cardiovascular risk in patients with PCOS.