Laterality Patterns of Brain Functional Connectivity: Gender Effects
Laterality Patterns of Brain Functional Connectivity: Gender Effects
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DOI：
10.1093/cercor/bhr230
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发表时间：
2012-06-01
期刊：
影响因子：
3.7
通讯作者：
Volkow, Nora D.
中科院分区：
文献类型：
--
作者：
Tomasi, Dardo;Volkow, Nora D.
大脑连接的偏侧化可能对正常的大脑功能至关重要，并且可能是性别二态性的。在这里，我们研究了短距离（涉及功能专业化）和长距离（涉及功能整合）连接的偏侧模式和性别对这些偏侧模式的影响。使用并行计算来量化913名健康受试者的短程和长程功能连接密度。短距离连接在外侧沟周围的区域是不对称的，而长距离连接在外侧沟是不对称的，在下前额叶皮层和角回是不对称的。后下枕叶皮质是单侧的（短距离和长距离连接）。男性在上级颞叶（短距离和长距离）、下额叶和下枕叶皮层（短距离）的大脑连接有更大的偏侧化，而女性在下额叶皮层的长距离连接有更大的偏侧化。男性大脑的偏侧化程度更高（主要是短距离），这可能是他们更容易患上大脑不对称性紊乱（精神分裂症、自闭症）的原因。
Lateralization of brain connectivity may be essential for normal brain function and may be sexually dimorphic. Here, we study the laterality patterns of short-range (implicated in functional specialization) and long-range (implicated in functional integration) connectivity and the gender effects on these laterality patterns. Parallel computing was used to quantify short- and long-range functional connectivity densities in 913 healthy subjects. Short-range connectivity was rightward lateralized and most asymmetrical in areas around the lateral sulcus, whereas long-range connectivity was rightward lateralized in lateral sulcus and leftward lateralizated in inferior prefrontal cortex and angular gyrus. The posterior inferior occipital cortex was leftward lateralized (short- and long-range connectivity). Males had greater rightward lateralization of brain connectivity in superior temporal (short- and long-range), inferior frontal, and inferior occipital cortices (short-range), whereas females had greater leftward lateralization of long-range connectivity in the inferior frontal cortex. The greater lateralization of the male's brain (rightward and predominantly short-range) may underlie their greater vulnerability to disorders with disrupted brain asymmetries (schizophrenia, autism).