A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome
A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome
复制标题
DOI：
10.1016/j.metabol.2011.07.013
复制
发表时间：
2012-03-01
影响因子：
9.8
通讯作者：
Fernandez, Maria Luz
中科院分区：
文献类型：
--
作者：
Jones, Jennifer L.;Comperatore, Michael;Fernandez, Maria Luz
目的是评估地中海式低血糖负荷饮食（对照组，n = 41）和相同饮食加上含有植物甾醇、大豆蛋白、酒花和金合花提取物的医疗食品（MF组，n = 42）对代谢综合征女性脂蛋白粥样硬化的影响。在干预的基线、第8周和第12周测量血浆脂质、载脂蛋白（apos）、脂蛋白亚组分和颗粒大小、低密度脂蛋白（LDL）氧化和脂蛋白(a)。在同一时间点收集三天的饮食记录以评估依从性。与基线相比，女性从碳水化合物（P < 0.001）和脂肪（P < 0.001）中摄入的能量减少，而从蛋白质中摄入的能量增加（P < 0.001）。单不饱和脂肪酸也显著增加了能量，二十碳五烯酸和二十二碳六烯酸也增加了，而反式脂肪酸的摄入量减少了（P < 0.00001）。致动脉粥样硬化脂蛋白，大的极低密度脂蛋白（P < 0.0001）和小的LDL （P < 0.0001）减少，而大的高密度脂蛋白与小的高密度脂蛋白颗粒的比例增加（P < 0.0001）。载脂蛋白B在所有女性中均降低（P < 0.0001），其中MF组降低幅度更大（P < 0.025）。在干预结束时，两组的氧化LDL （P < 0.05）和脂蛋白(a) （P < 0.001）均降低。地中海式饮食通过降低致动脉粥样硬化脂蛋白、氧化LDL和载脂蛋白b来降低心血管疾病的风险(C) 2012 Elsevier Inc.。版权所有。
The objective was to assess the impact of a Mediterranean-style, low-glycemic-load diet (control group, n = 41) and the same diet plus a medical food (MF) containing phytosterols, soy protein, and extracts from hops and Acacia (MF group, n = 42) on lipoprotein atherogenicity in women with metabolic syndrome. Plasma lipids, apolipoproteins (apos), lipoprotein subfractions and particle size, low-density lipoprotein (LDL) oxidation, and lipoprotein (a) were measured at baseline, week 8, and week 12 of the intervention. Three-day dietary records were collected at the same time points to assess compliance. Compared with baseline, women decreased energy intake from carbohydrate (P < .001) and fat (P < .001), whereas they increased energy intake from protein (P < .001). A significant increase in energy from monounsaturated fatty acids was also observed as well as increases in eicosapentaenoic acid and docosahexaenoic acid, whereas trans-fatty acid intake was reduced (P < .00001). The atherogenic lipoproteins, large very low-density lipoprotein (P < .0001) and small LDL (P < .0001), were reduced, whereas the ratio of large high-density lipoprotein to smaller high-density lipoprotein particles was increased (P < .0001). Apolipoprotein B was reduced for all women (P < .0001), with a greater reduction in the MF group (P < .025). Oxidized LDL (P < .05) and lipoprotein (a) (P < .001) were reduced in both groups at the end of the intervention. Consumption of a Mediterranean-style diet reduces the risk for cardiovascular disease by decreasing atherogenic lipoproteins, oxidized LDL, and apo B. Inclusion of an MF may have an additional effect in reducing apo B. (C) 2012 Elsevier Inc. All rights reserved.