Single-particle cryo-EM-How did it get here and where will it go.
Single-particle cryo-EM-How did it get here and where will it go.
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DOI：
10.1126/science.aat4346
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发表时间：
2018-08-31
期刊：
影响因子：
--
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Cheng Y
Electron cryo-microscopy, or simply cryo-EM, refers mainly to three very different yet closely related techniques: electron crystallography, single particle cryo-EM and electron cryo-tomography. In the past few years, single particle cryo-EM in particular has triggered a revolution in structural biology and has become a newly dominant discipline. This review examines the fascinating story of its start and evolution over the past forty plus years, delves into how and why the recent technological advances have been so ground-breaking, and briefly considers where the technique may be headed in the future.
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