Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.
Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.
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DOI：
10.3390/ijms18071544
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发表时间：
2017-07-17
影响因子：
5.6
通讯作者：
Cho SG
中科院分区：
文献类型：
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作者：
Saha SK;Lee SB;Won J;Choi HY;Kim K;Yang GM;Dayem AA;Cho SG
营养摄入不足或过量会导致氧化应激，这可能会破坏氧化稳态，激活级联分子途径，并改变各种组织的代谢状态。几种食物和消费模式与各种癌症有关，大约30-35%的癌症病例与营养过剩或营养不良有关。然而，关于饮食与癌症风险之间的关系，有几项相互矛盾的研究，仍有待阐明。同时，氧化应激是癌症进展和治疗的关键因素。营养氧化应激可能是由于营养供应不足或过量导致抗氧化防御和促氧化负荷之间的失衡而引起的。氧化应激是一种生理状态，其中产生高水平的活性氧（ROS）和自由基。与肿瘤发生相关的几种信号通路可以额外控制ROS的产生并调节ROS下游机制，这可能在抗癌研究中具有潜在的意义。癌症的发生可能受到营养介导的ROS水平升高的调节，ROS水平升高可以通过触发DNA突变、损伤和促癌信号传导来刺激癌症的发生。因此，在这篇综述中，我们概述了营养、氧化应激和癌症发生之间的关系，并评估了营养介导的抗氧化能力调节对癌症治疗的影响。
Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic status of various tissues. Several foods and consumption patterns have been associated with various cancers and approximately 30–35% of the cancer cases are correlated with overnutrition or malnutrition. However, several contradictory studies are available regarding the association between diet and cancer risk, which remains to be elucidated. Concurrently, oxidative stress is a crucial factor for cancer progression and therapy. Nutritional oxidative stress may be induced by an imbalance between antioxidant defense and pro-oxidant load due to inadequate or excess nutrient supply. Oxidative stress is a physiological state where high levels of reactive oxygen species (ROS) and free radicals are generated. Several signaling pathways associated with carcinogenesis can additionally control ROS generation and regulate ROS downstream mechanisms, which could have potential implications in anticancer research. Cancer initiation may be modulated by the nutrition-mediated elevation in ROS levels, which can stimulate cancer initiation by triggering DNA mutations, damage, and pro-oncogenic signaling. Therefore, in this review, we have provided an overview of the relationship between nutrition, oxidative stress, and cancer initiation, and evaluated the impact of nutrient-mediated regulation of antioxidant capability against cancer therapy.