Incidence of parkinsonism and Parkinson disease in a general population - The Rotterdam Study
Incidence of parkinsonism and Parkinson disease in a general population - The Rotterdam Study
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DOI：
10.1212/01.wnl.0000140706.52798.be
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发表时间：
2004-10-12
期刊：
影响因子：
9.9
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
--
作者：
de Lau, LML;Giesbergen, PCLM;Breteler, MMB
目的：采用现场筛查沿着临床数据，研究普通人群中帕金森综合征和帕金森病（PD）的发病率。研究方法：在鹿特丹研究中，一项针对年龄大于或等于55岁人群的前瞻性基于人群的队列研究，作者评估了6，839名基线时无帕金森症的参与者中帕金森症和PD的年龄和性别特异性发病率。病例发现包括在基线和两次随访时的亲自筛查，通过计算机连接全科医生和药房记录对队列进行连续监测，获得额外信息。结果：在平均5.8年的随访期后，确定了132例帕金森综合征患者，其中67例（51%）患有PD。帕金森综合征和PD的发生率随年龄增加而增加，PD的发生率从55 - 65岁受试者的0.3/1000人-年增加到85岁或以上受试者的4.4/1000人-年。任何帕金森综合征的总体年龄校正发生率在男性和女性中没有差异，但男性似乎具有更高的PD风险（男女比，1. 54; 95% CI，0. 95 - 2. 51）。结论：帕金森综合征和帕金森病的发病率高于大多数以前的研究报告，可能是因为作者密集的病例发现方法，包括亲自筛查。
Objective: To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using in-person screening along with clinical data. Methods: In the Rotterdam study, a prospective population-based cohort study of people aged greater than or equal to 55 years, the authors assessed age- and sex-specific incidence rates of parkinsonism and PD among 6,839 participants who were free of parkinsonism at baseline. Case finding involved in-person screening at baseline and two follow-up visits, and additional information was obtained through continuous monitoring of the cohort by computer linkage to general practitioners' and pharmacy records. Results: After a mean follow-up period of 5.8 years, 132 subjects with incident parkinsonism were identified, of whom 67 (51%) had PD. The incidence of parkinsonism and PD increased with age, with incidence rates for PD increasing from 0.3 per 1000 person-years in subjects aged 55 to 65 years, to 4.4 per 1000 person-years for those aged greater than or equal to85 years. The overall age- adjusted incidence rate of any parkinsonism was not different in men and women, but men seem to have a higher risk for PD (male-to-female ratio, 1.54; 95% CI, 0.95 to 2.51). Conclusion: Incidence rates for parkinsonism and Parkinson disease were higher than those reported by most previous studies, possibly because of the authors' intensive case-finding methods involving in-person screening.