Simultaneous assessment of diameter and pressure waveforms in the carotid artery
Simultaneous assessment of diameter and pressure waveforms in the carotid artery
复制标题
DOI：
10.1016/j.ultrasmedbio.2003.10.014
复制
发表时间：
2004-02-01
影响因子：
2.9
通讯作者：
Hoeks, APG
中科院分区：
文献类型：
--
作者：
Meinders, JM;Hoeks, APG
直径和压力波形的同时评估允许计算作为扩张压力的函数的增量顺应性、扩张性、脉搏波速度和弹性模量。然而，波形必须在相同的位置处获得，并且利用相同的滤波器特性来采集和处理，以避免幅度和相位的可能的时间和空间变化。在本文中，动脉直径波形的超声（US）的手段进行评估，并转换为压力使用经验推导出的指数关系的压力和动脉横截面。通过迭代地改变壁刚性系数（即，指数幂）。因为压力直接从动脉横截面导出，所以不会由于空间分离或不同的滤波器特性而引入相位延迟。对51例年龄在22 ~ 75岁之间的健康人的左颈总动脉进行了评价。在健康受试者中，颈动脉脉压比肱动脉脉压低29%。动脉特性的连续评估证实，脉搏波速度和增量弹性模量增加，而扩张性和顺应性降低，作为增加扩张血压的函数。
Simultaneous assessment of diameter and pressure waveforms allows the calculation of the incremental compliance, distensibility, pulse wave velocity and elastic modulus as function of the distending pressure. However, the waveforms must be obtained at the same position and acquired and processed with the same filter characteristics to circumvent possible temporal and spatial changes in amplitude and phase. In this paper, arterial diameter waveforms are assessed by means of ultrasound (US) and converted to pressure using an empirically derived exponential relationship between pressure and arterial cross-section. The derived pressure waveform is calibrated to brachial end diastolic and mean arterial pressure by iteratively changing the wall rigidity coefficient (i.e., the exponential power). Because pressure is derived directly from arterial cross-section, no phase delay is introduced due to spatial separation or different filter characteristics. The method was evaluated for the left common carotid artery of 51 healthy subjects ranging in age from 22 to 75 years old. In healthy subjects, the carotid pulse pressure is 29% lower than the brachial pulse pressure. Continuous assessment of arterial properties confirms that pulse-wave velocity and incremental elastic modulus increase, whereas distensibility and compliance decrease, as function of increasing distending blood pressure.