Susceptibility locus for Alzheimer's disease on chromosome 10
Susceptibility locus for Alzheimer's disease on chromosome 10
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DOI：
10.1126/science.290.5500.2304
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发表时间：
2000-12-22
期刊：
影响因子：
56.9
通讯作者：
Goate, AM
中科院分区：
文献类型：
--
作者：
Myers, A;Holmans, P;Goate, AM
载脂蛋白E（APOE）基因是迄今为止唯一与迟发性阿尔茨海默病（LOAD）风险相关的遗传风险因素，然而，50%的阿尔茨海默病病例不携带APOE 4等位基因，这表明必须存在其他风险因素。我们用LOAD在同胞对中进行了两阶段全基因组筛选以检测其他易感基因座。在这里，我们报告的证据阿尔茨海默氏病基因座上的10号染色体。我们的第一阶段多点Lod评分（连锁/无连锁比值比的对数）为2.48（266个兄弟姐妹对），在第二阶段（429个兄弟姐妹对）增加到3.83，接近D10 S1225（79厘摩）。该基因座改变阿尔茨海默病的风险，与APOE基因型无关。
The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been Linked to risk for Late-onset Alzheimer's disease (LOAD), However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility Loci. Here we report evidence for an Alzheimer's disease Locus on chromosome 10. Our stage one multipoint Lod score (Logarithm of the odds ratio for linkage/no Linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This Locus modifies risk for Alzheimer's disease independent of APOE genotype.