Improved in vitro quantification of the force exerted by the papillary muscle on the left ventricular wall:: Three-dimensional force vector measurement system
Improved in vitro quantification of the force exerted by the papillary muscle on the left ventricular wall:: Three-dimensional force vector measurement system
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DOI：
10.1114/1.1366672
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发表时间：
2001-05-01
影响因子：
3.8
通讯作者：
Yoganathan, AP
中科院分区：
文献类型：
--
作者：
Jensen, MOJ;Fontaine, AA;Yoganathan, AP
最近的发展表明，作用于乳头肌的力可以衡量二尖瓣返流的严重程度。病理情况，如缺血性心脏病，会引起左心室和二尖瓣环几何形状的改变，通常导致乳头肌相对于二尖瓣环的移位。这可能会导致肌腱索张力增加。这种增加的张力被传递到瓣叶，并可能扰乱二尖瓣的粘合模式。各个部件上的力平衡控制着二尖瓣的功能。测量二尖瓣关闭不全从正常状态到病理状态的力分布变化的能力可能有助于深入了解二尖瓣关闭不全的机制。一种独特的体外模型已经被开发出来，该模型可以量化乳头肌的空间位置和乳头肌施加于左室壁的三维力矢量。该系统允许量化在模拟正常和疾病条件下从乳头肌施加在左后室壁上的整体力。(C)2001年生物医学工程学会。
Recent developments indicate that the forces acting on the papillary muscles can be a measure of the severity of mitral valve regurgitation. Pathological conditions, such as ischemic heart disease, cause changes in the geometry of the left ventricle and the mitral valve annulus, often resulting in displacement of the papillary muscles relative to the annulus. This can lead to increased tension in the chordae tendineae. This increased tension is transferred to the leaflets, and can disturb the coaptation pattern of the mitral valve. The force balance on the individual components governs the function of the mitral valve. The ability to measure changes in the force distribution from normal to pathological conditions may give insight into the mechanisms of mitral valve insufficiency. A unique in vitro model has been developed that allows quantification of the papillary muscle spatial position and quantification of the three-dimensional force vector applied to the left ventricular wall by the papillary muscles. This system allows for the quantification of the global force exerted on the posterior left ventricular wall from the papillary muscles during simulation of normal and diseased conditions. (C) 2001 Biomedical Engineering Society.