Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection.
Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection.
复制标题
神经生长因子 (NGF) 的中和可抑制 Th2 反应并防止呼吸道合胞病毒 (RSV) 感染。
DOI：
10.1007/s12026-017-8909-z
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Wang Jun
中科院分区：
文献类型：
--
作者：
Wu Xiaorong;Zhou Xiong;Hu Yuxiang;Liu Chao;Wang Jun
越来越多的证据表明，生命早期呼吸道合胞病毒（RSV）感染是哮喘发生的重要危险因素。RSV感染与气道的神经源性炎症以及神经生长因子（NGF）的表达增加有关。然而，NGF在RSV感染中的作用尚不清楚。在本研究中，我们用RSV感染大鼠，并用抗ngf中和抗体处理这些动物。我们发现抗ngf治疗明显减轻了肺部炎症，炎症浸润减少，气道阻力降低。重要的是，抗ngf治疗导致Th1升高，但Th2免疫应答降低，促进了组织和血液中的病毒控制。因此，在RSV感染中，NGF抑制Th2，但增加Th1反应。严重呼吸道合胞病毒感染期间NGF信号的药物干预可以预防或减少进一步的哮喘症状。
Increasing evidence suggests that respiratory syncytial virus (RSV) infection during the early life is an important risk factor for the development of asthma. RSV infection is associated with neurogenic inflammation in the airways along with the increased expression of nerve growth factor (NGF). However, the role of NGF in RSV infection is not clear. In this study, we infected the rat with RSV and treated these animals with anti-NGF neutralization antibody. We found that anti-NGF treatment significantly alleviated the lung inflammation as evidenced by decreased inflammatory infiltration and decreased airway resistance. Importantly, anti-NGF treatment resulted in increased Th1, but decreased Th2 immune responses, and facilitated the viral control in the tissues and blood. Therefore, NGF inhibited Th2 but increased Th1 responses in RSV infection. Pharmacological intervention of NGF signaling during severe RSV infections could prevent or decrease further asthma symptoms.