Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden
Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden
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DOI：
10.5853/jos.2017.02565
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发表时间：
2018-05-01
影响因子：
8.2
通讯作者：
Peters, Nils
中科院分区：
文献类型：
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作者：
Duering, Marco;Konieczny, Marek J.;Peters, Nils
背景与目的神经丝轻链（Neurolaminallight chain，NfL）是神经轴索损伤的血液标志物.我们评估了血清NfL与脑小血管病（SVD）之间的关系，脑小血管病在老年人中高度流行，是中风和血管性认知障碍的主要原因。方法采用横断面设计，我们研究了53例和439例遗传定义的SVD患者，（常染色体显性脑动脉病伴皮质下I型病变和白质脑病[CADASIL]）和散发性SVD，以及93名健康对照。通过超灵敏单分子阵列测定法测量血清NfL。我们量化了SVD的磁共振成像（MRI）标记物，即，从扩散张量成像获得的白色高信号体积、腔隙体积、脑体积、微出血计数和平均扩散率。临床表征包括两种SVD样本的神经心理学测试。CADASIL患者进一步进行局灶性神经功能缺损（美国国立卫生研究院卒中量表[NIHSS]）和残疾（改良兰金量表[mRS]）的表征。
Background and Purpose Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly prevalent in elderly individuals and a major cause of stroke and vascular cognitive impairmentMethods Using a cross-sectional design, we studied 53 and 439 patients with genetically defined SVD (Cerebral Autosomal-Dominant Arteriopathy with Subcortica I Infarcts and Leukoencephalopathy [CADASIL]) and sporadic SVD, respectively, as well as 93 healthy controls. Serum NfL was measured by an ultrasensitive single-molecule array assay. We quantified magnetic resonance imaging (MRI) markers of SVD, i.e., white matter hyperintensity volume, lacune volume, brain volume, microbleed count, and mean diffusivity obtained from diffusion tensor imaging. Clinical characterization included neuropsychological testing in both SVD samples. CADASIL patients were further characterized for focal neurological deficits (National Institutes of Health stroke scale [NIHSS]) and disability (modified Rankin scale [mRS]).Results Serum NfL levels were elevated in both SVD samples (P