Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1
Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1
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DOI：
10.3109/10715762.2011.581279
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发表时间：
2011-07-01
影响因子：
3.3
通讯作者：
Fukumoto, Manabu
中科院分区：
文献类型：
--
作者：
Roudkenar, Mehryar Habibi;Halabian, Raheleh;Fukumoto, Manabu
中性粒细胞明胶酶相关的Lipocalin(NGAL/Lcn2)是Lipocalin家族的一员，具有多种功能。有广泛的研究检测NGAL在有害条件下的表达。然而，它的确切功能仍然知之甚少。血红素加氧酶1(HO-1)是一种公认的具有细胞保护作用的酶。前期工作表明NGAL可诱导HO-1的表达。有趣的是，同样的刺激诱导了NGAL和HO-1的表达。本研究旨在(1)确定NGAL是否通过HO-1发挥其细胞保护作用；(2)比较NGAL和HO-1对氧化应激的保护作用。目前的数据表明，NGAL发挥其独立于HO-1的细胞保护作用，并且比HO-1更有效地保护细胞免受氧化应激。这些数据还强烈表明，在有害条件下诱导NGAL是改善氧化应激介导的毒性的代偿反应。这些发现可能会建议NGAL的新应用，特别是在氧化应激是主要因素的情况下。
Neutrophil Gelatinase-Associated Lipocalin (NGAL/Lcn2), a member of the lipocalin family, has a variety of functions. There are extensive studies examining the expression of NGAL under harmful conditions. However, its precise function remains poorly understood. Heme Oxygenase 1 (HO-1) is an enzyme with well-established cytoprotective effects. Previous work showed that NGAL induces expression of HO-1. Interestingly, the same stimuli induced the expression of both NGAL and HO-1. The current study was designed to (1) determine whether NGAL exerts its cytoprotective effect through HO-1 and (2) compare NGAL and HO-1 with each other in terms of their protective role against oxidative stress. The current data indicate that NGAL exerts its cytoprotective effect independent of HO-1 and protects cells against oxidative stress more efficiently than HO-1. The data also strongly suggest that induction of NGAL under harmful conditions is a compensatory response to ameliorate oxidative stress-mediated toxicity. These findings may suggest new applications of NGAL, particularly when oxidative stress is a major factor.