Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats.
Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats.
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DOI：
10.1016/j.fct.2010.05.074
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Xiaolan Yang;Lei Yang;Haiying Zheng
中科院分区：
文献类型：
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作者：
Xiaolan Yang;Lei Yang;Haiying Zheng
对桑树冻干粉的植物化学成分进行了研究。测定果实(MFP)含量。在高脂饮食或正常饮食中添加5%或10%MFP的大鼠，评价了MFP作为膳食补充剂的降血脂和抗氧化作用。高脂饮食大鼠服用MFP后，血清和肝脏甘油三酯、总胆固醇、血清低密度脂蛋白胆固醇水平明显下降，动脉粥样硬化指数降低，而血清高密度脂蛋白胆固醇水平显著升高。此外，血清和肝脏中脂质过氧化产物硫代巴比妥酸相关物质的含量显著降低，而红细胞和肝脏的超氧化物歧化酶(SOD)和全血谷胱甘肽过氧化物酶(GSH-Px)活性显著升高。补充MFP的正常饮食大鼠的血清和肝脏中的脂类分布没有明显变化，但血液和肝脏的抗氧化状态有所改善，通过测定SOD和GSH-Px的活性，并减少了脂质过氧化。MFP对高脂血症大鼠的这些有益作用可能与其膳食纤维、脂肪酸、酚类、类黄酮类、花青素、维生素和微量元素的含量有关。
The phytochemical constituents of a freeze-dried powder of mulberry (Morus alba L.) fruit (MFP) were determined. The hypolipidemic and antioxidant effects of the MFP as a dietary supplement were evaluated in rats who were fed 4 weeks of either a high-fat or a normal diet supplemented with 5% or 10% MFP. Administration of MFP to rats on a high-fat diet resulted in a significant decline in levels of serum and liver triglyceride, total cholesterol, serum low-density lipoprotein cholesterol, and a decrease in the atherogenic index, while the serum high-density lipoprotein cholesterol was significantly increased. In addition, the serum and liver content of thiobarbituric acid related substances, a lipid peroxidation product, significantly decreased, while the superoxide dismutase (SOD) of red blood cell and liver, as well blood glutathione peroxidase (GSH-Px) activities significantly increased. No significant changes in lipid profile in the serum and liver were observed in rats on a normal diet supplemented with MFP, but blood and liver antioxidant status improved, as measured by SOD and GSH-Px activity, and lipid peroxidation was reduced. These beneficial effects of MFP on hyperlipidaemia rats might be attributed to its dietary fiber, fatty acids, phenolics, flavonoids, anthocyanins, vitamins and trace elements content.